Safety Evaluation of Oral Toxicity of Carica papaya Linn. Leaves: A Subchronic Toxicity Study in Sprague Dawley Rats
Joint Authors
Abdullah, Noor Rain
Halim, Siti Zaleha
Abdul Rashid, Badrul Amini
Jantan, Ibrahim
Ismail, Zakiah
Afzan, Adlin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The subchronic toxicity effect of the leaf extract of Carica papaya Linn.
in Sprague Dawley (SD) rats was investigated in this study.
The extract was prepared by dissolving the freeze dried extract of the leaves in distilled water and was administered orally to SD rats (consisted of 10 rats/sex/group) at 0 (control), 0.01, 0.14, and 2 g/kg body weight (BW) for 13 weeks.
General observation, mortality, and food and water intake were monitored throughout the experimental period.
Hematological and biochemical parameters, relative organ weights, and histopathological changes were evaluated.
The study showed that leaf extract when administered for 13 weeks did not cause any mortality and abnormalities of behavior or changes in body weight as well as food and water intake.
There were no significant differences observed in hematology parameters between treatment and control groups; however significant differences were seen in biochemistry values, for example, LDH, creatinine, total protein, and albumin.
However, these changes were not associated with histopathological changes.
In conclusion, the results suggested that daily oral administration of rats with C.
papaya leaf extract for 13 weeks at a dose up to fourteen times the levels employed in traditional medicine practice did not cause any significant toxic effect.
American Psychological Association (APA)
Ismail, Zakiah& Halim, Siti Zaleha& Abdullah, Noor Rain& Afzan, Adlin& Abdul Rashid, Badrul Amini& Jantan, Ibrahim. 2014. Safety Evaluation of Oral Toxicity of Carica papaya Linn. Leaves: A Subchronic Toxicity Study in Sprague Dawley Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035355
Modern Language Association (MLA)
Ismail, Zakiah…[et al.]. Safety Evaluation of Oral Toxicity of Carica papaya Linn. Leaves: A Subchronic Toxicity Study in Sprague Dawley Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035355
American Medical Association (AMA)
Ismail, Zakiah& Halim, Siti Zaleha& Abdullah, Noor Rain& Afzan, Adlin& Abdul Rashid, Badrul Amini& Jantan, Ibrahim. Safety Evaluation of Oral Toxicity of Carica papaya Linn. Leaves: A Subchronic Toxicity Study in Sprague Dawley Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035355