Changes in Responses of Neurons in Spinal and Medullary Subnucleus Reticularis Dorsalis to Acupoint Stimulation in Rats with Visceral Hyperalgesia
Joint Authors
Qin, Qing-Guang
Huang, Guo-Fu
Yu, Lingling
Li, Liang
Rong, Peijing
Ben, Hui
Zhu, Bing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this study was to explore the mechanism of acupoints sensitization phenomenon at the spinal and medulla levels.
Experiments were performed on adult male Sprague-Dawley rats and visceral noxious stimuli was generated by colorectal distension (CRD).
The activities of wide dynamic range (WDR) and subnucleus reticularis dorsalis (SRD) neurons were recorded.
The changes of the reactions of WDR and SRD neurons to electroacupuncture (EA) on acupoints of “Zusanli-Shangjuxu” before and after CRD stimulation were observed.
The results showed that visceral nociception could facilitate the response of neurons to acupoints stimulation.
In spinal dorsal horn, EA-induced activation of WDR neurons further increased to 106.84 ± 17.33% (1.5 mA) (P<0.001) and 42.27 ± 13.10% (6 mA) (P<0.01) compared to the neuronal responses before CRD.
In medulla oblongata, EA-induced activation of SRD neurons further increased to 63.28 ± 15.96% (1.5 mA) (P<0.001) and 25.02 ± 7.47% (6 mA) (P<0.01) compared to that before CRD.
Taken together, these data suggest that the viscerosomatic convergence-facilitation effect of WDR and SRD neurons may underlie the mechanism of acupoints sensitization.
But the sensitizing effect of visceral nociception on WDR neurons is stronger than that on SRD neurons.
American Psychological Association (APA)
Yu, Lingling& Li, Liang& Rong, Peijing& Zhu, Bing& Qin, Qing-Guang& Ben, Hui…[et al.]. 2014. Changes in Responses of Neurons in Spinal and Medullary Subnucleus Reticularis Dorsalis to Acupoint Stimulation in Rats with Visceral Hyperalgesia. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035363
Modern Language Association (MLA)
Yu, Lingling…[et al.]. Changes in Responses of Neurons in Spinal and Medullary Subnucleus Reticularis Dorsalis to Acupoint Stimulation in Rats with Visceral Hyperalgesia. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035363
American Medical Association (AMA)
Yu, Lingling& Li, Liang& Rong, Peijing& Zhu, Bing& Qin, Qing-Guang& Ben, Hui…[et al.]. Changes in Responses of Neurons in Spinal and Medullary Subnucleus Reticularis Dorsalis to Acupoint Stimulation in Rats with Visceral Hyperalgesia. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035363