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Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK12 Phosphorylation after Pressure Overload
Joint Authors
Zhou, Miao
Guo, Liheng
Liu, Qin
Gong, Kaizheng
Wang, Lei
Zhang, Minzhou
Yu, Juan
Qi, Jianyong
Wu, Jiashin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Cardiac hypertrophy occurs in many cardiovascular diseases.
Apocynum tablet (AT), a traditional Chinese medicine, has been widely used in China to treat patients with hypertension.
However, the underlying molecular mechanisms of AT on the hypertension-induced cardiac hypertrophy remain elusive.
The current study evaluated the effect and mechanisms of AT on cardiac hypertrophy.
Methods.
We created a mouse model of cardiac hypertrophy by inducing pressure overload with surgery of transverse aortic constriction (TAC) and then explored the effect of AT on the development of cardiac hypertrophy using 46 mice in 4 study groups (combinations of AT and TAC).
In addition, we evaluated the signaling pathway of phosphorylation of ERK1/2, AKT, and protein expression of GATA4 in the cardioprotective effects of AT using Western blot.
Results.
AT inhibited the phosphorylation of Thr202/Tyr204 sites of ERK1/2, Ser473 site of AKT, and protein expression of GATA4 and significantly inhibited cardiac hypertrophy and cardiac fibrosis at 2 weeks after TAC surgery (P<0.05).
Conclusions.
We experimentally demonstrated that AT inhibits cardiac hypertrophy via suppressing phosphorylation of ERK1/2 and AKT.
American Psychological Association (APA)
Qi, Jianyong& Liu, Qin& Gong, Kaizheng& Yu, Juan& Wang, Lei& Guo, Liheng…[et al.]. 2014. Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK12 Phosphorylation after Pressure Overload. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035364
Modern Language Association (MLA)
Qi, Jianyong…[et al.]. Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK12 Phosphorylation after Pressure Overload. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035364
American Medical Association (AMA)
Qi, Jianyong& Liu, Qin& Gong, Kaizheng& Yu, Juan& Wang, Lei& Guo, Liheng…[et al.]. Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK12 Phosphorylation after Pressure Overload. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035364