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Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages
Joint Authors
Kummer, Raquel
Cuman, Roberto Kenji Nakamura
Silva, Expedito Leite
Silva-Comar, Francielli Maria de Souza
Wiirzler, Luiz Alexandre Marques
Silva-Filho, Saulo Euclides
Pedroso, Raissa Bocchi
Spironello, Ricardo Alexandre
Bersani-Amado, Ciomar Aparecida
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Estragole, a chemical constituent of the essential oils of many aromatic plants, is used as flavoring in beverage and food industries.
In vivo and in vitro experimental assays have shown that EST has sedative, anticonvulsant, antioxidant, antimicrobial, and anesthetic activity.
In this work, we evaluate the effect of EST on leukocyte behavior and phagocytic activity of macrophages.
In the peritonitis model, EST (500 and 750 mg/kg) decreased the infiltration of peritoneal exudate leukocytes.
In vitro chemotaxis assay showed that EST (3, 10, 30, and 60 μg/mL) inhibited neutrophil migration toward fMLP.
In the in vivo microcirculation assay, EST at doses of 250, 500, and 750 mg/kg significantly reduced the number of rolling and adherent leukocytes and at doses of 250 and 500 mg/kg decreased number of leukocyte migrated to perivascular tissue.
The results showed that EST (3, 10, and 30 μg/mL) was able to stimulate the macrophages phagocytosis but only at concentration of 10 μg/mL promoted an increase in nitric oxide (NO) production.
In conclusion, this study showed that EST had potential anti-inflammatory effects, likely by inhibiting leukocyte migration and by stimulating macrophages phagocytosis.
American Psychological Association (APA)
Silva-Comar, Francielli Maria de Souza& Wiirzler, Luiz Alexandre Marques& Silva-Filho, Saulo Euclides& Kummer, Raquel& Pedroso, Raissa Bocchi& Spironello, Ricardo Alexandre…[et al.]. 2014. Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035367
Modern Language Association (MLA)
Silva-Comar, Francielli Maria de Souza…[et al.]. Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035367
American Medical Association (AMA)
Silva-Comar, Francielli Maria de Souza& Wiirzler, Luiz Alexandre Marques& Silva-Filho, Saulo Euclides& Kummer, Raquel& Pedroso, Raissa Bocchi& Spironello, Ricardo Alexandre…[et al.]. Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035367