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Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes
Joint Authors
Ximenes, Valdecir Farias
Paracatu, Luana Chiquetto
Faria, Carolina Maria Quinello Gomes
Rennó, Camila
Zeraik, Maria Luiza
Palmeira, Patricia
da Fonseca, Luiz Marcos
Quinello, Camila
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Numerous anti-inflammatory properties have been attributed to caffeic acid phenethyl ester (CAPE), an active component of propolis.
NADPH oxidases are multienzymatic complexes involved in many inflammatory diseases.
Here, we studied the importance of the CAPE hydrophobicity on cell-free antioxidant capacity, inhibition of the NADPH oxidase and hypochlorous acid production, and release of TNF-α and IL-10 by activated leukocytes.
The comparison was made with the related, but less hydrophobic, caffeic and chlorogenic acids.
Cell-free studies such as superoxide anion scavenging assay, triene degradation, and anodic peak potential ( E pa ) measurements showed that the alterations in the hydrophobicity did not provoke significant changes in the oxidation potential and antiradical potency of the tested compounds.
However, only CAPE was able to inhibit the production of superoxide anion by activated leukocytes.
The inhibition of the NADPH oxidase resulted in the blockage of production of hypochlorous acid.
Similarly, CAPE was the more effective inhibitor of the release of TNF-α and IL-10 by Staphylococcus aureus stimulated cells.
In conclusion, the presence of the catechol moiety and the higher hydrophobicity were essential for the biological effects.
Considering the involvement of NADPH oxidases in the genesis and progression of inflammatory diseases, CAPE should be considered as a promising anti-inflammatory drug.
American Psychological Association (APA)
Paracatu, Luana Chiquetto& Faria, Carolina Maria Quinello Gomes& Quinello, Camila& Rennó, Camila& Palmeira, Patricia& Zeraik, Maria Luiza…[et al.]. 2014. Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035371
Modern Language Association (MLA)
Paracatu, Luana Chiquetto…[et al.]. Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1035371
American Medical Association (AMA)
Paracatu, Luana Chiquetto& Faria, Carolina Maria Quinello Gomes& Quinello, Camila& Rennó, Camila& Palmeira, Patricia& Zeraik, Maria Luiza…[et al.]. Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035371