Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL6J and Triple Transgenic Alzheimer’s Mice
Joint Authors
Hsieh-Li, Hsiu Mei
Chen, Wei-Lin
Hsieh, Rong-Hong
Hsieh-Li, Hsiu Mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-01
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Mangosteen- (Garcinia mangostana-) based nutraceutical compounds have long been reported to possess multiple health-promoting properties.
The current study investigated whether mangosteen pericarp (MP) could attenuate cognitive dysfunction.
First, we found that treatment with MP significantly reduced the cell death and increased the brain-derived neurotrophic factor (BDNF) level in an organotypic hippocampal slice culture (OHSC).
We then investigated the effects of age and MP diet on the cognitive function of male C57BL/6J (B6) mice.
After 8-month dietary supplementation, the MP diet (5000 ppm) significantly attenuated the cognitive impairment associated with anti-inflammation, increasing BDNF level and decreasing p-tau (phospho-tau S202) in older B6 mice.
We further applied MP dietary supplementation to triple transgenic Alzheimer’s disease (3×Tg-AD) mice from 5 to 13 months old.
The MP diet exerted neuroprotective, antioxidative, and anti-inflammatory effects and reduced the Aβ deposition and p-tau (S202/S262) levels in the hippocampus of 3×Tg-AD mice, which might further attenuate the deficit in spatial memory retrieval.
Thus, these results revealed that the multifunctional properties of MP might offer a promising supplementary diet to attenuate cognitive dysfunction in AD.
American Psychological Association (APA)
Hsieh-Li, Hsiu Mei& Chen, Wei-Lin& Hsieh, Rong-Hong& Hsieh-Li, Hsiu Mei. 2014. Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL6J and Triple Transgenic Alzheimer’s Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1035378
Modern Language Association (MLA)
Hsieh-Li, Hsiu Mei…[et al.]. Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL6J and Triple Transgenic Alzheimer’s Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1035378
American Medical Association (AMA)
Hsieh-Li, Hsiu Mei& Chen, Wei-Lin& Hsieh, Rong-Hong& Hsieh-Li, Hsiu Mei. Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL6J and Triple Transgenic Alzheimer’s Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1035378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035378