Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study
Joint Authors
Kamiya, Takeshi
Tanida, Satoshi
Shikano, Michiko
Tanaka, Mamoru
Katano, Takahito
Hamano, Shingo
Nishiwaki, Hirotaka
Tsukamoto, Hironobu
Okuda, Noriaki
Kubota, Eiji
Ozeki, Keiji
Joh, Takashi
Mori, Yoshinori
Ebi, Masahide
Mizoshita, Tsutomu
Kataoka, Hiromi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Recently, it was revealed that low grade mucosal inflammation and/or immune imbalance of the lower digestive tract is one of the mechanisms involved in symptom generation in patients with irritable bowel syndrome (IBS).
Biobran, arabinoxylan compound derived from rice bran, has been reported to have several biological actions such as anti-inflammatory and immune modulatory effects.
So we investigated the therapeutic effects of Biobran in patients with IBS.
Method.
Forty patients with diarrhea predominant or mixed type IBS were randomly assigned to either a Biobran group for treatment with Biobran or a placebo group.
Therapeutic efficacy and IBS symptoms were assessed subjectively by the patients after 4 weeks of administration.
Results.
The global assessment was effective in 63.2% of the Biobran group and in 30% of the placebo group ( P < 0.05 , Biobran group versus placebo group).
Biobran group showed a significant decrease in the score of diarrhea and constipation and in CRP value.
However, no significant changes were observed in the placebo group.
Conclusion.
The administration of Biobran improved IBS symptoms.
It is likely that anti-inflammatory and/or immune modulatory effects of Biobran might be useful in IBS patients.
American Psychological Association (APA)
Kamiya, Takeshi& Shikano, Michiko& Tanaka, Mamoru& Ozeki, Keiji& Ebi, Masahide& Katano, Takahito…[et al.]. 2014. Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035390
Modern Language Association (MLA)
Kamiya, Takeshi…[et al.]. Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035390
American Medical Association (AMA)
Kamiya, Takeshi& Shikano, Michiko& Tanaka, Mamoru& Ozeki, Keiji& Ebi, Masahide& Katano, Takahito…[et al.]. Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035390