Phytochemical Constituents and Toxicity of Duguetia furfuracea Hydroalcoholic Extract in Drosophila melanogaster
Joint Authors
Augusti Boligon, Aline
Valéria Soares de Araújo Pinho, Francisca
Felipe da Silva, Gustavo
Echeverria Macedo, Giulianna
Raquel Muller, Katiane
Kemmerich Martins, Illana
Lausmann Ternes, Ana Paula
Martins da Costa, José Galberto
Kamdem, Jean Paul
Franco, Jeferson Luis
Rose Alencar de Menezes, Irwin
Posser, Thaís
Athayde, Margareth Linde
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Duguetia furfuracea is frequently used as a medicinal plant in Brazil.
However, studies have evidenced its cytotoxic, bactericide, and antitumor activities.
In the present study we aimed to evaluate the potential toxicity of hydroalcoholic leaves extracts of D.
furfuracea (HEDF) in a Drosophila melanogaster model.
Toxicity was assessed as changes in locomotor performance, mitochondrial activity, oxidative stress, MAPKs phosphorylation, and apoptosis induction after exposure to HEDF concentrations (1–50 mg/mL) for 7 days.
The phytoconstituents of the plant were screened for the presence of alkaloids, tannins, xanthones, chalcones, flavonoids, aurones, and phenolic acids.
Exposure of adult flies to HEDF caused mitochondrial dysfunction, overproduction of ROS, and alterations in the activity of detoxifying enzymes GST, SOD and CAT.
Induction of ERK phosphorylation and PARP cleavage was also observed, indicating occurrence of HEDF-induced cell stress and apoptotic cell death.
In parallel, alterations in cholinesterase activity and impairments in negative geotaxis behavior were observed.
Our study draws attention to the indiscriminate use of this plant by population and suggests oxidative stress as a major mechanism underlying its toxicity.
American Psychological Association (APA)
Valéria Soares de Araújo Pinho, Francisca& Felipe da Silva, Gustavo& Echeverria Macedo, Giulianna& Raquel Muller, Katiane& Kemmerich Martins, Illana& Lausmann Ternes, Ana Paula…[et al.]. 2014. Phytochemical Constituents and Toxicity of Duguetia furfuracea Hydroalcoholic Extract in Drosophila melanogaster. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035405
Modern Language Association (MLA)
Valéria Soares de Araújo Pinho, Francisca…[et al.]. Phytochemical Constituents and Toxicity of Duguetia furfuracea Hydroalcoholic Extract in Drosophila melanogaster. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035405
American Medical Association (AMA)
Valéria Soares de Araújo Pinho, Francisca& Felipe da Silva, Gustavo& Echeverria Macedo, Giulianna& Raquel Muller, Katiane& Kemmerich Martins, Illana& Lausmann Ternes, Ana Paula…[et al.]. Phytochemical Constituents and Toxicity of Duguetia furfuracea Hydroalcoholic Extract in Drosophila melanogaster. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035405