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Yiqihuoxuejiedu Formula Inhibits Vascular Remodeling by Reducing Proliferation and Secretion of Adventitial Fibroblast after Balloon Injury
Joint Authors
Ai-Ming, Wu
Gao, Yonghong
Wang, Jie
Chang, Hong
Liu, Hui-Min
Lv, Xi-Ying
Lei, Huan
Sun, Qing-Qin
Xu, Ying
He, Ying-Kun
Wang, Shuoren
Zhao, Mingjing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Vascular remodeling occurs in atherosclerosis, hypertension, and restenosis after percutaneous coronary intervention.
Adventitial remodeling may be a potential therapeutic target.
Yiqihuoxuejiedu formula uses therapeutic principles from Chinese medicine to supplement Qi, activate blood circulation, and resolve toxin and it has been shown to inhibit vascular stenosis.
To investigate effects and mechanisms of the formula on inhibiting vascular remodeling, especially adventitial remodeling, rats with a balloon injury to their common carotid artery were used and were treated for 7 or 28 days after injury.
The adventitial area and α-SMA expression increased at 7 days after injury, which indicated activation and proliferation of adventitial fibroblasts.
Yiqihuoxuejiedu formula reduced the adventitial areas at 7 days, attenuated the neointima and vessel wall area, stenosis percent, and α-SMA expression in the neointima, and reduced collagen content and type I/III collagen ratio in the adventitia at 28 days.
Yiqihuoxuejiedu formula had more positive effects than Captopril in reducing intimal proliferation and diminishing stenosis, although Captopril lowered neointimal α-SMA expression and reduced the collagen content at 28 days.
Yiqihuoxuejiedu formula has inhibitory effects on positive and negative remodeling by reducing adventitial and neointimal proliferation, reducing content, and elevating adventitial compliance.
American Psychological Association (APA)
Zhao, Mingjing& Ai-Ming, Wu& Wang, Jie& Chang, Hong& Gao, Yonghong& Liu, Hui-Min…[et al.]. 2014. Yiqihuoxuejiedu Formula Inhibits Vascular Remodeling by Reducing Proliferation and Secretion of Adventitial Fibroblast after Balloon Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035418
Modern Language Association (MLA)
Zhao, Mingjing…[et al.]. Yiqihuoxuejiedu Formula Inhibits Vascular Remodeling by Reducing Proliferation and Secretion of Adventitial Fibroblast after Balloon Injury. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035418
American Medical Association (AMA)
Zhao, Mingjing& Ai-Ming, Wu& Wang, Jie& Chang, Hong& Gao, Yonghong& Liu, Hui-Min…[et al.]. Yiqihuoxuejiedu Formula Inhibits Vascular Remodeling by Reducing Proliferation and Secretion of Adventitial Fibroblast after Balloon Injury. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035418