The Effects of Loranthus parasiticus on Scopolamine-Induced Memory Impairment in Mice
Joint Authors
Eom, Min Rye
Ma, Choong Je
Lee, Jiwoo
Jung, Youn Sik
Weon, Jin Bae
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study is undertaken to evaluate cognitive enhancing effect and neuroprotective effect of Loranthus parasiticus.
Cognitive enhancing effect of Loranthus parasiticus was investigated on scopolamine-induced amnesia model in Morris water maze test and passive avoidance test.
We also examined the neuroprotective effect on glutamate-induced cell death in HT22 cells by MTT assay.
These results of Morris water maze test and passive avoidance test indicated that 10 and 50 mg/kg of Loranthus parasiticus reversed scopolamine-induced memory deficits.
Loranthus parasiticus also protected against glutamate-induced cytotoxicity in HT22 cells.
As a result of in vitro test for elucidating possible mechanism, Loranthus parasiticus inhibited AChE activity, ROS production, and Ca2+ accumulation.
Loranthus parasiticus showed memory enhancing effect and neuroprotective effect and these effects may be related to inhibition of AChE activity, ROS level, and Ca2+ influx.
American Psychological Association (APA)
Weon, Jin Bae& Lee, Jiwoo& Eom, Min Rye& Jung, Youn Sik& Ma, Choong Je. 2014. The Effects of Loranthus parasiticus on Scopolamine-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035428
Modern Language Association (MLA)
Weon, Jin Bae…[et al.]. The Effects of Loranthus parasiticus on Scopolamine-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035428
American Medical Association (AMA)
Weon, Jin Bae& Lee, Jiwoo& Eom, Min Rye& Jung, Youn Sik& Ma, Choong Je. The Effects of Loranthus parasiticus on Scopolamine-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035428