Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model
Joint Authors
Huang, Wei-Jan
Hsu, Feng-Lin
Tsai, Keng-Chang
Chen, Chen-Yu
Huang, Chi-Chang
Huang, Wen-Ching
Hsu, Yu-Chen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases.
To evaluate the antihyperuricemic effect of Davallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6,8-dihydroxychromone-7-C-β-d-glucopyranoside (1), 6,8,3′,4′-tetrahydroxyflavanone-7-C-β-d-glucopyranoside (2), 6,8,4′-trihydroxyflavanone-7-C-β-d-glucopyranoside (3), 8-(2-pyrrolidinone-5-yl)-catechin-3-O-β-d-allopyranoside (4), and epiphyllocoumarin-3-O-β-d-allopyranoside (5), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model.
The results indicated that compounds 3 and 5 significantly inhibited XOD activity in vitro and reduced serum uric acid levels in vivo.
This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.
American Psychological Association (APA)
Chen, Chen-Yu& Huang, Chi-Chang& Tsai, Keng-Chang& Huang, Wei-Jan& Huang, Wen-Ching& Hsu, Yu-Chen…[et al.]. 2014. Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035432
Modern Language Association (MLA)
Chen, Chen-Yu…[et al.]. Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035432
American Medical Association (AMA)
Chen, Chen-Yu& Huang, Chi-Chang& Tsai, Keng-Chang& Huang, Wei-Jan& Huang, Wen-Ching& Hsu, Yu-Chen…[et al.]. Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035432