Clinical Usefulness of Oral Supplementation with Alpha-Lipoic Acid, Curcumin Phytosome, and B-Group Vitamins in Patients with Carpal Tunnel Syndrome Undergoing Surgical Treatment

Abstract EN

We investigated the clinical usefulness of oral supplementation with a combination product containing alpha-lipoic acid, curcumin phytosome, and B-group vitamins in 180 patients with carpal tunnel syndrome (CTS), scheduled to undergo surgical decompression of the median nerve.

Patients in Group A ( n = 60 ) served as controls and did not receive any treatment either before or after surgery.

Patients in Group B ( n = 60 ) received oral supplementation twice a day for 3 months both before and after surgery (totaling 6 months of supplementation).

Patients in Group C ( n = 60 ) received oral supplementation twice a day for 3 months before surgery only.

Patients in Group B showed significantly lower nocturnal symptoms scores compared with Group A subjects at both 40 days and 3 months after surgery (both P values < 0.05 ).

Moreover, patients in Group B had a significantly lower number of positive Phalen’s tests at 3 months compared with the other study groups ( P < 0.05 ).

We conclude that oral supplementation with alpha-lipoic acid, curcumin phytosome, and B-group vitamins twice a day both before and after surgery is safe and effective in CTS patients scheduled to undergo surgical decompression of the median nerve.