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Shen-Zhi-Ling Oral Liquid Improves Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease
Joint Authors
Wang, Qiudong
Kwak, Shin
Wang, Mingzhe
Yamamoto, Yoshiharu
Song, Yu
Qin, Baofeng
Pan, Weidong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We evaluated the effects of the traditional Chinese medicine (TCM) Shen-Zhi-Ling oral liquid (SZL) on the behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer’s disease (AD).
Among 98 patients with AD and BPSD enrolled (mean age, 57.2 ± 8.9 years old), 91 (M = 55, F = 36; mean age, 57.2 ± 9.7 years old) completed the study.
Patients took either SZL ( n = 45 ) or placebo granules ( n = 46 ) in a double-blind manner for 20 weeks while maintaining other anticognitive medications unchanged.
Changes in BPSD between week 0, week 10, week 20, and week 25 were assessed using the behavioral pathology in Alzheimer’s disease (BEHAVE-AD) rating scale and the neuropsychiatric inventory (NPI), detrended fluctuation analysis (DFA) represented by diurnal activity (DA), evening activity (EA), and nocturnal activity (NA) according to actigraphic recordings.
SZL but not placebo oral liquid delayed the development of BPSD significantly according to the changes in some of the clinical scores and the EA and NA parameters of DFA at week 20 compared with week 0.
No side effects were observed in laboratory tests.
The results indicate that SZL might delay the development of BPSD in AD patients and thus is a potentially suitable drug for long-term use.
American Psychological Association (APA)
Pan, Weidong& Wang, Qiudong& Kwak, Shin& Song, Yu& Qin, Baofeng& Wang, Mingzhe…[et al.]. 2014. Shen-Zhi-Ling Oral Liquid Improves Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035450
Modern Language Association (MLA)
Pan, Weidong…[et al.]. Shen-Zhi-Ling Oral Liquid Improves Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035450
American Medical Association (AMA)
Pan, Weidong& Wang, Qiudong& Kwak, Shin& Song, Yu& Qin, Baofeng& Wang, Mingzhe…[et al.]. Shen-Zhi-Ling Oral Liquid Improves Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035450