An Immunomodulatory Protein (Ling Zhi-8) from a Ganoderma lucidum Induced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery
Joint Authors
Ou, Keng-Liang
Lin, Hao-Jan
Chang, Yushan-Sophie
Lin, Li-Hsiang
Haung, Chiung-Fang
Wu, Chia-Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The purpose of this study was to investigate the effect of an immunomodulatory protein (Ling Zhi-8, LZ-8) on wound healing in rat liver tissues after monopolar electrosurgery.
Animals were sacrificed for evaluations at 0, 3, 7, and 28 days postoperatively.
It was found that the wound with the LZ-8 treatment significantly increases wound healing.
Western blot analysis clearly indicated that the expression of NF- κ B was decreased at 3, 7, and 28 days when liver tissues were treated with LZ-8.
Moreover, caspase-3 activity of the liver tissue also significantly decreases at 7 and 28 days, respectively.
DAPI staining and TUNEL assays revealed that only a minimal dispersion of NF- κ B was found on the liver tissue treated with LZ-8 at day 7 as compared with day 3 and tissues without LZ-8 treatment.
Similarly, apoptosis was decreased on liver tissues treated with LZ-8 at 7 days when compared to the control (monopolar electrosurgery) tissues.
Therefore, the analytical results demonstrated that LZ-8 induced acceleration of wound healing in rat liver tissues after monopolar electrosurgery.
American Psychological Association (APA)
Lin, Hao-Jan& Chang, Yushan-Sophie& Lin, Li-Hsiang& Haung, Chiung-Fang& Wu, Chia-Yu& Ou, Keng-Liang. 2014. An Immunomodulatory Protein (Ling Zhi-8) from a Ganoderma lucidum Induced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035453
Modern Language Association (MLA)
Lin, Hao-Jan…[et al.]. An Immunomodulatory Protein (Ling Zhi-8) from a Ganoderma lucidum Induced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1035453
American Medical Association (AMA)
Lin, Hao-Jan& Chang, Yushan-Sophie& Lin, Li-Hsiang& Haung, Chiung-Fang& Wu, Chia-Yu& Ou, Keng-Liang. An Immunomodulatory Protein (Ling Zhi-8) from a Ganoderma lucidum Induced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035453