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Policosanol Attenuates Statin-Induced Increases in Serum Proprotein Convertase SubtilisinKexin Type 9 When Combined with Atorvastatin
Joint Authors
Guo, Yuan-Lin
Li, Jianjun
Xu, Rui-Xia
Zhu, Cheng-Gang
Wu, Na-Qiong
Cui, Zhi-Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Statin treatment alone has been demonstrated to significantly increase plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels.
The effect of policosanol combined with statin on PCSK9 is unknown.
Methods.
Protocol I: 26 patients with atherosclerosis were randomly assigned to receive either atorvastatin 20 mg/d or policosanol 20 mg/d + atorvastatin 20 mg/d for 8 weeks.
Protocol II: 15 healthy volunteers were randomly assigned to either policosanol 20 mg/d or a control group for 12 weeks.
Serum levels of PCSK9 were determined at day 0 and the end of each protocol.
Results.
Protocol I: atorvastatin 20 mg/d significantly increased serum PCSK9 level by 39.4% (256 ± 84 ng/mL versus 357 ± 101 ng/mL, P = 0.002 ).
However, policosanol 20 mg/d + atorvastatin 20 mg/d increased serum PCSK9 level by only 17.4% without statistical significance (264 ± 60 ng/mL versus 310 ± 86 ng/mL, P = 0.184 ).
Protocol II: there was a trend toward decreasing serum PCSK9 levels in the policosanol group (289 ± 71 ng/mL versus 235 ± 46 ng/mL, P = 0.069 ).
Conclusion.
Policosanol combined with statin attenuated the statin-induced increase in serum PCSK9 levels.
This finding indicates that policosanol might have a modest effect of lowering serum PCSK9 levels.
American Psychological Association (APA)
Guo, Yuan-Lin& Xu, Rui-Xia& Zhu, Cheng-Gang& Wu, Na-Qiong& Cui, Zhi-Ping& Li, Jianjun. 2014. Policosanol Attenuates Statin-Induced Increases in Serum Proprotein Convertase SubtilisinKexin Type 9 When Combined with Atorvastatin. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035457
Modern Language Association (MLA)
Guo, Yuan-Lin…[et al.]. Policosanol Attenuates Statin-Induced Increases in Serum Proprotein Convertase SubtilisinKexin Type 9 When Combined with Atorvastatin. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035457
American Medical Association (AMA)
Guo, Yuan-Lin& Xu, Rui-Xia& Zhu, Cheng-Gang& Wu, Na-Qiong& Cui, Zhi-Ping& Li, Jianjun. Policosanol Attenuates Statin-Induced Increases in Serum Proprotein Convertase SubtilisinKexin Type 9 When Combined with Atorvastatin. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035457