P6 Electroacupuncture Improved QTc Interval Prolongation by Upregulation of Connexin43 in Droperidol Treated Rats
Joint Authors
Zhao, Feng
Cui, Suyang
Huang, Libing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
This study investigated the effect of P6 EA on droperidol-induced QTc interval prolongation and Cx43 expression in ventricular muscle of rats.
Methods.
Twenty-four rats were randomly divided into control group (C), droperidol group (D), or EA group (E).
C group rats were injected with normal saline.
D group rats were injected with droperidol 0.13 mg/kg.
E group rats were pretreated with EA at left P6 acupoint for 30 min and then injected with droperidol (0.13 mg/kg).
QTc intervals were recorded at lead II in ECG within 120 min.
Cx43 expression was measured by RT-PCR and western blotting.
Result.
Droperidol significantly prolonged QTc intervals compared with controls at 5 min, 10 min, 15 min, and 30 min ( P < 0.05 ).
P6 EA could significantly abbreviate the prolongation of QTc interval compared with droperidol group at 5 min, 10 min, 15 min, and 30 min ( P < 0.05 ).
Cx43 mRNA and proteins were significantly increased by P6 EA compared with droperidol group at 120 min ( P < 0.05 ).
There were no significant differences in Cx43 mRNA and protein expression between droperidol and control group at 120 min ( P > 0.05 ).
Conclusion.
P6 EA could improve QTc interval prolongation induced by droperidol, which may relate to upregulation of Cx43 mRNA and protein.
Antiemetic dose of droperidol had minor effects on Cx43 mRNA and protein expression at 120 min.
American Psychological Association (APA)
Zhao, Feng& Cui, Suyang& Huang, Libing. 2014. P6 Electroacupuncture Improved QTc Interval Prolongation by Upregulation of Connexin43 in Droperidol Treated Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035459
Modern Language Association (MLA)
Zhao, Feng…[et al.]. P6 Electroacupuncture Improved QTc Interval Prolongation by Upregulation of Connexin43 in Droperidol Treated Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1035459
American Medical Association (AMA)
Zhao, Feng& Cui, Suyang& Huang, Libing. P6 Electroacupuncture Improved QTc Interval Prolongation by Upregulation of Connexin43 in Droperidol Treated Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035459