Effects of Stingless Bee Propolis on Experimental Asthma
Joint Authors
Nascimento, F. R. F.
Assunção, Anne Karine Martins
Reis, Aramys Silva dos
Costa, Graciomar Conceição
Guerra, Rosane Nassar Meireles
Farias, José Hidelbland Cavalcante de
Araújo, Marcio Antonio Rodrigues
Farias, Jardel Cavalcante de
Fialho, Eder Magalhães Silva
Silva, Lucilene Amorim
Ribeiro, Maria Nilce Sousa
Araújo, Maria José Abigail Mendes
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bee products have been used empirically for centuries, especially for the treatment of respiratory diseases.
The present study evaluated the effect of treatment with a propolis hydroalcoholic extract (PHE) produced by Scaptotrigona aff.
postica stingless bee in a murine asthma model.
BALB/c mice were immunized twice with ovalbumin (OVA) subcutaneously.
After 14 days, they were intranasally challenged with OVA.
Groups P50 and P200 received PHE by gavage at doses of 50 and 200 mg/kg, respectively.
The DEXA group was treated with intraperitoneal injection of dexamethasone.
The OVA group received only water.
The mice were treated daily for two weeks and then they were immunized a second time with intranasal OVA.
The treatment with PHE decreased the cell number in the bronchoalveolar fluid (BAL).
Histological analysis showed reduced peribronchovascular inflammation after treatment with PHE especially the infiltration of polymorphonuclear cells.
In addition, the concentration of interferon-γ (IFN-γ) in the serum was decreased.
These results were similar to those obtained with dexamethasone.
Treatment with S.
aff postica propolis reduced the pathology associated with murine asthma due an inhibition of inflammatory cells migration to the alveolar space and the systemic progression of the allergic inflammation.
American Psychological Association (APA)
Farias, José Hidelbland Cavalcante de& Reis, Aramys Silva dos& Araújo, Marcio Antonio Rodrigues& Araújo, Maria José Abigail Mendes& Assunção, Anne Karine Martins& Farias, Jardel Cavalcante de…[et al.]. 2014. Effects of Stingless Bee Propolis on Experimental Asthma. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035478
Modern Language Association (MLA)
Farias, José Hidelbland Cavalcante de…[et al.]. Effects of Stingless Bee Propolis on Experimental Asthma. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035478
American Medical Association (AMA)
Farias, José Hidelbland Cavalcante de& Reis, Aramys Silva dos& Araújo, Marcio Antonio Rodrigues& Araújo, Maria José Abigail Mendes& Assunção, Anne Karine Martins& Farias, Jardel Cavalcante de…[et al.]. Effects of Stingless Bee Propolis on Experimental Asthma. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035478