The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA1J Mouse Rheumatoid Arthritis
Joint Authors
Kwon, O. Gon
An, Hee Duk
Lee, Young-Joon
Ku, Sae-Kwang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The object of this study is to observe the effects of platycodin D, a saponin purified from Platycodi Radix, on mice collagen-induced arthritis (CIA).
A daily dose of 200, 100, and 50 mg/kg platycodin D was administered orally to male DBA/1J mice for 40 days after initial collagen immunization.
To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) was measured from histopathological changes in the spleen, left popliteal lymph node, third digit, and the knee joint regions.
CIA-related bone and cartilage damage improved significantly in the platycodin D-administered CIA mice.
Additionally, myeloperoxidase (MPO) levels in the paw were reduced in platycodin D-treated CIA mice compared to CIA control groups.
The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dose-dependent manner in the platycodin D group.
Finally, the production of IL-6 and TNF-α, involved in rheumatoid arthritis pathogenesis, was suppressed by treatment with platycodin D.
Taken together, these results suggest that platycodin D is a promising new effective antirheumatoid arthritis agent, exerting anti-inflammatory, antioxidative and immunomodulatory effects in CIA mice.
American Psychological Association (APA)
Kwon, O. Gon& Ku, Sae-Kwang& An, Hee Duk& Lee, Young-Joon. 2014. The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA1J Mouse Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1035480
Modern Language Association (MLA)
Kwon, O. Gon…[et al.]. The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA1J Mouse Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1035480
American Medical Association (AMA)
Kwon, O. Gon& Ku, Sae-Kwang& An, Hee Duk& Lee, Young-Joon. The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA1J Mouse Rheumatoid Arthritis. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1035480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035480