Essential Oils from Fructus A. zerumbet Protect Human Aortic Endothelial Cells from Apoptosis Induced by Ox-LDL In Vitro
Joint Authors
Chen, Yan
Li, Duo
Xu, Yini
Zhang, Yanyan
Tao, Ling
Li, Shouqiao
Jiang, Yan
Shen, Xiangchun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alpinia zerumbet is a miao folk medicinal plant widely used in the Guizhou Province of southwest China that contains several bioactive constituents and possesses protective effects against cardiovascular diseases.
In the present study, we evaluated the protective effect of essential oils derived from Fructus Alpiniae zerumbet (EOFAZ) on oxidized lowdensity-lipoprotein- (ox-LDL-) induced apoptosis in human aortic endothelial cells (HAECs).
Following exposure to ox-LDL, HAECs presented with classical characteristics of apoptosis.
However, EOFAZ ameliorated these morphological alterations and also inhibited the decrease in cell viability.
In addition, EOFAZ abrogated the number of TUNEL or Hoechst 33258 stained positive cells observed after ox-LDL challenge.
Investigation into the mechanisms of this inhibition revealed that EOFAZ treatment resulted in a downregulation of Bax and Caspase-3 at both the protein and mRNA expression levels.
Moreover, EOFAZ was found to upregulate Bcl-2 protein and mRNA levels and to attenuate ox-LDL-induced HAECs injury caused by apoptosis, revealing both its therapeutic potential for endothelial cell injury protection and its clinical application for atherosclerosis.
American Psychological Association (APA)
Chen, Yan& Li, Duo& Xu, Yini& Zhang, Yanyan& Tao, Ling& Li, Shouqiao…[et al.]. 2014. Essential Oils from Fructus A. zerumbet Protect Human Aortic Endothelial Cells from Apoptosis Induced by Ox-LDL In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035482
Modern Language Association (MLA)
Chen, Yan…[et al.]. Essential Oils from Fructus A. zerumbet Protect Human Aortic Endothelial Cells from Apoptosis Induced by Ox-LDL In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035482
American Medical Association (AMA)
Chen, Yan& Li, Duo& Xu, Yini& Zhang, Yanyan& Tao, Ling& Li, Shouqiao…[et al.]. Essential Oils from Fructus A. zerumbet Protect Human Aortic Endothelial Cells from Apoptosis Induced by Ox-LDL In Vitro. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035482
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035482