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Anti-Trichophyton Activity of Protocatechuates and Their Synergism with Fluconazole
Joint Authors
Gullo, Fernanda P.
Sardi, Janaina C. O.
Sangalli-Leite, Fernanda
Pitangui, Nayla S.
Soares, Luciana A.
Fusco-Almeida, Ana Marisa
Costa-Orlandi, Caroline Barcelos
Scorzoni, Liliana
Petrônio, Maicon Segalla
Mendes-Giannini, Maria José Soares
Regasini, Luis Octávio
Souza, Patrícia Fernanda
Silva, Dulce Helena Siqueira
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dermatophytosis and superficial mycosis are a major global public health problem that affects 20–25% of the world’s population.
The increase in fungal resistance to the commercially available antifungal agents, in conjunction with the limited spectrum of action of such drugs, emphasises the need to develop new antifungal agents.
Natural products are attractive prototypes for antifungal agents due to their broad spectrum of biological activities.
This study aimed to verify the antifungal activity of protocatechuic acid, 3,4-diacetoxybenzoic, and fourteen alkyl protocatechuates (3,4-dihydroxybenzoates) against Trichophyton rubrum and Trichophyton mentagrophytes and to further assess their activities when combined with fluconazole.
Susceptibility and synergism assays were conducted as described in M38-A2 (CLSI), with modifications.
Three strains of Trichophyton rubrum and three strains of Trichophyton mentagrophytes were used in this work.
The pentyl, hexyl, heptyl, octyl, nonyl, and decyl protocatechuates showed great fungicidal effects, with minimum inhibitory concentration (MIC) values ranging from 0.97 to 7.8 mg/L.
Heptyl showed a synergistic activity (FIC index = 0.49 ), reducing the MIC of fluconazole by fourfold.
All substances tested were safe, especially the hexyl, heptyl, octyl, and nonyl compounds, all of which showed a high selectivity index, particularly in combination with fluconazole.
These ester associations with fluconazole may represent a promising source of prototypes in the search for anti-Trichophyton therapeutic agents.
American Psychological Association (APA)
Soares, Luciana A.& Gullo, Fernanda P.& Sardi, Janaina C. O.& Pitangui, Nayla S.& Costa-Orlandi, Caroline Barcelos& Sangalli-Leite, Fernanda…[et al.]. 2014. Anti-Trichophyton Activity of Protocatechuates and Their Synergism with Fluconazole. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035485
Modern Language Association (MLA)
Soares, Luciana A.…[et al.]. Anti-Trichophyton Activity of Protocatechuates and Their Synergism with Fluconazole. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035485
American Medical Association (AMA)
Soares, Luciana A.& Gullo, Fernanda P.& Sardi, Janaina C. O.& Pitangui, Nayla S.& Costa-Orlandi, Caroline Barcelos& Sangalli-Leite, Fernanda…[et al.]. Anti-Trichophyton Activity of Protocatechuates and Their Synergism with Fluconazole. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035485