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Prolonged Diuretic Activity and Calcium-Sparing Effect of Tropaeolum majus: Evidence in the Prevention of Osteoporosis
Joint Authors
Botelho Lourenço, Emerson Luiz
Gasparotto Junior, Arquimedes
Gasparotto, Francielly Mourão
Barboza, Lorena Neris
Prando, Thiago Bruno Lima
Dalsenter, Paulo Roberto
Gasparotto, Francielli
Jacomassi, Ezilda
Araújo, Valdinei de Oliveira
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Although several studies indicate high effectiveness in the use of the hydroethanolic extract from Tropaeolum majus (HETM) as a diuretic, the impact of its prolonged use in the presence of low estrogen levels remains unclear.
Thus, the aim of this study was to investigate the diuretic effects of prolonged administration of HETM in ovariectomized rats and their interrelationship between calcium excretion and bone turnover.
Forty-two female Wistar rats were ovariectomized (OVX) and treated orally with different doses of HETM (3, 30, and 300 mg/kg) for 4 weeks.
On the first day of treatment and at weekly intervals for four weeks the diuretic activity was evaluated.
Electrolyte concentrations and creatinine levels were estimated from urine sample of each rat.
The serum lipids, urea, creatinine, and osteocalcin were also measured at the end of the experiment.
The data revealed that the HETM was able to sustain its diuretic effect after prolonged treatment.
Moreover, its use has not affected the urinary calcium or potassium excretion, reduces lipid levels, and maintains osteocalcin levels similarly to untreated rats.
These findings support the potential of HETM as a candidate to be used in clinical conditions in which the renal loss of calcium is not desired.
American Psychological Association (APA)
Barboza, Lorena Neris& Prando, Thiago Bruno Lima& Dalsenter, Paulo Roberto& Gasparotto, Francielly Mourão& Gasparotto, Francielli& Jacomassi, Ezilda…[et al.]. 2014. Prolonged Diuretic Activity and Calcium-Sparing Effect of Tropaeolum majus: Evidence in the Prevention of Osteoporosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035486
Modern Language Association (MLA)
Barboza, Lorena Neris…[et al.]. Prolonged Diuretic Activity and Calcium-Sparing Effect of Tropaeolum majus: Evidence in the Prevention of Osteoporosis. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035486
American Medical Association (AMA)
Barboza, Lorena Neris& Prando, Thiago Bruno Lima& Dalsenter, Paulo Roberto& Gasparotto, Francielly Mourão& Gasparotto, Francielli& Jacomassi, Ezilda…[et al.]. Prolonged Diuretic Activity and Calcium-Sparing Effect of Tropaeolum majus: Evidence in the Prevention of Osteoporosis. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035486