A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

Abstract EN

Background.

Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which include cancer, inflammation, and infection.

The aim of this review is to report the pharmacological potential of plants of Clusiaceae family with the anti-inflammatory activity in animal experiments.

Methods.

A systematic review about experiments investigating anti-inflammatory activity of Clusiaceae family was carried out by searching bibliographic databases such as Medline, Scopus and Embase.

In this update, the search terms were “anti-inflammatory agents,” “Clusiaceae,” and “animals, laboratory.” Results.

A total of 255 publications with plants this family were identified.

From the initial 255 studies, a total of 21 studies were selected for the final analysis.

Studies with genera Allanblackia, Clusia, Garcinia or Rheedia, and Hypericum showed significant anti-inflammatory activity.

The findings include a decrease of total leukocytes, a number of neutrophils, total protein concentration, granuloma formation, and paw or ear edema formation.

Other interesting findings included decreased of the MPO activity, and inflammatory mediators such as NF-κB and iNOS expression, PGE2 and Il-1β levels and a decrease in chronic inflammation.

Conclusion.

The data reported suggests the anti-inflammatory effect potential of Clusiaceae family in animal experiments.