A Study on the Effect of Neurogenesis and Regulation of GSK3βPP2A Expression in Acupuncture Treatment of Neural Functional Damage Caused by Focal Ischemia in MCAO Rats
Joint Authors
Luo, Ding
Fan, Xiaonong
Ma, Congcong
Fan, Tongtao
Wang, Xiaoguang
Chang, Nvzi
Li, Lingxin
Zhang, Yanan
Meng, Zhihong
Wang, Shu
Shi, Xuemin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
170 SD rats were randomly divided to five groups.
Rats in model group, no-acupuncture group, and acupuncture group were subjected to MCAO surgery.
Acupuncture group received 3 consecutive acupuncture treatments at a parameter that deep in 2 mm towards apex nasi and thrust/lifted at 3 times per second for 1 minute, while model group and no-acupuncture group were no-intervention control groups.
Serious neural functional damage and sharp decrease of cerebral blood flow, obvious infarction volume, increased nestin mRNA expression, and immunopositive cells population (nestin+, BrdU+ and nestin/BrdU+) were found in MCAO rats which had not been observed in normal group and sham-operated group.
However, the damage was attenuated by rat’s “self-healing” capacity 3 days after MCAO.
And the “self-healing” capacity can be strengthen by acupuncture treatment through increasing cerebral blood flow, neurogenesis, and regulation of gene transcription or GSK-3β and PP2A expression.
In conclusion, the present study indicates that the underlying mechanism of acupuncture treatment on neural functional damage caused by focal ischemia injury is a multiple interaction which may involve improved cerebral blood supply, neurogenesis, and regulation of gene transcription or GSK-3β and PP2A expression in MCAO rats.
American Psychological Association (APA)
Luo, Ding& Fan, Xiaonong& Ma, Congcong& Fan, Tongtao& Wang, Xiaoguang& Chang, Nvzi…[et al.]. 2014. A Study on the Effect of Neurogenesis and Regulation of GSK3βPP2A Expression in Acupuncture Treatment of Neural Functional Damage Caused by Focal Ischemia in MCAO Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035496
Modern Language Association (MLA)
Luo, Ding…[et al.]. A Study on the Effect of Neurogenesis and Regulation of GSK3βPP2A Expression in Acupuncture Treatment of Neural Functional Damage Caused by Focal Ischemia in MCAO Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1035496
American Medical Association (AMA)
Luo, Ding& Fan, Xiaonong& Ma, Congcong& Fan, Tongtao& Wang, Xiaoguang& Chang, Nvzi…[et al.]. A Study on the Effect of Neurogenesis and Regulation of GSK3βPP2A Expression in Acupuncture Treatment of Neural Functional Damage Caused by Focal Ischemia in MCAO Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035496