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Evaluation of Analgesic Activity of the Methanol Extract from the Galls of Quercus infectoria (Olivier) in Rats
Joint Authors
Basri, Dayang Fredalina
Fan, Sook-Ha
Ali, Noraisah Akbar
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present study aims to investigate the analgesic activity of the methanol extract of the galls of Quercus infectoria in rats using hot plate and tail-flick methods.
The extract was administered intraperitoneally at a dose of 20 mg/kg while morphine sulfate and sodium salicylate (10 mg/kg) served as standards.
The methanol extract exhibited significant analgesic activity in the tail-flick model (P<0.05) by increasing the reaction time of the rats to 8.0 sec at 30 min after treatment in comparison to control (4.4 sec).
Morphine sulfate produced a reaction time of 11.9 sec in the same test.
At the peak of activity (30 min), the extract produced maximum possible analgesia (MPA) of 34.2%, whilst morphine sulfate achieved a peak MPA of 70.9%.
No analgesic effects have been observed using sodium salicylate in the tail-flick model.
In the same model, the extract and sodium salicylate demonstrated comparable reaction times.
Tail-flick is a better method to evaluate analgesic activity as no significant results were observed for all treatments using hot plate with the exception of morphine sulfate, which showed significant results only at 45 and 60 min after treatment.
In conclusion, the methanol extract of the galls of Quercus infectoria displayed analgesic activity.
American Psychological Association (APA)
Fan, Sook-Ha& Ali, Noraisah Akbar& Basri, Dayang Fredalina. 2014. Evaluation of Analgesic Activity of the Methanol Extract from the Galls of Quercus infectoria (Olivier) in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035517
Modern Language Association (MLA)
Fan, Sook-Ha…[et al.]. Evaluation of Analgesic Activity of the Methanol Extract from the Galls of Quercus infectoria (Olivier) in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035517
American Medical Association (AMA)
Fan, Sook-Ha& Ali, Noraisah Akbar& Basri, Dayang Fredalina. Evaluation of Analgesic Activity of the Methanol Extract from the Galls of Quercus infectoria (Olivier) in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035517