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Anticancer Effect of Fucoidan in Combination with Tyrosine Kinase Inhibitor Lapatinib
Joint Authors
Kim, Jihun
Lu, Weidong
Rosenthal, David
Oh, Byeongsang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Despite a number of in vitro and in vivo studies reporting the efficacy of fucoidan in treating various cancers, few studies have measured the efficacy of dietary fucoidan (DF) in combination with cancer drugs.
Thus, we examined the sensitivity of DF in combination with the EGFR/ERBB2-targeting reagent lapatinib on cancer cells.
Method.
We selected six EGFR/ERBB2-amplified cancer cell lines (OE19, NCI-N87, OE33, ESO26, MKN7, and BT474) as an in vitro model and tested their sensitivity to DF alone and to DF in combination with the well-known EGFR/ERBB2-targeting reagent lapatinib.
Result.
Overall, in drug independent sensitivity test, DF alone did not significantly inhibit the growth of EGFR/ERBB2-amplified cancer cells in vitro.
When DF was given in combination with lapatinib, however, it tended to synergistically inhibit cell growth in OE33 but antagonized the action of lapatinib in ESO26, NCI-N87, and OE19.
Conclusion.
This study suggests that DF has the potential to increase or decrease the effects of certain anticancer drugs on certain cancer cell types.
Further study is needed to explore the mechanism of interaction and synergistic antitumor activity of DF in combination with chemotherapy and targeted therapy.
American Psychological Association (APA)
Oh, Byeongsang& Kim, Jihun& Lu, Weidong& Rosenthal, David. 2014. Anticancer Effect of Fucoidan in Combination with Tyrosine Kinase Inhibitor Lapatinib. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035830
Modern Language Association (MLA)
Oh, Byeongsang…[et al.]. Anticancer Effect of Fucoidan in Combination with Tyrosine Kinase Inhibitor Lapatinib. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035830
American Medical Association (AMA)
Oh, Byeongsang& Kim, Jihun& Lu, Weidong& Rosenthal, David. Anticancer Effect of Fucoidan in Combination with Tyrosine Kinase Inhibitor Lapatinib. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035830