Effectiveness and Safety of S-1-Based Therapy Compared with 5-Fluorouracil-Based Therapy for Advanced Colorectal Cancer: A Meta-Analysis
Joint Authors
Ye, Jiaxiang
Chen, Jiawei
Ge, Lianying
Liu, Aiqun
Zhou, Shaozhang
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
The aim of our study was to compare the efficacy and safety of S-1-based therapy (SBT) versus 5-fluorouracil-based therapy (FBT) for advanced colorectal cancer (ACRC).
Methods.
A meta-analysis of all eligible randomized controlled trials (RCTs) was performed using RevMan 5.1.0 software.
Results.
A total of 1625 patients from twelve RCTs including 820 patients in the SBT group and 805 patients in the FBT group were available for analysis.
The meta-analysis of overall survival (hazards ratio HR = 0.94, 95% CI = 0.80–1.10), progression-free survival (HR = 1.03, 95% CI = 0.91–1.18), and overall response rate (odds ratio OR = 1.23, 95% CI = 1.00–1.53) showed no statistical significance between SBT group and FBT group.
The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 neutropenia (OR = 0.49, 95% CI = 0.35–0.68) and nausea/vomit (OR = 0.41, 95% CI = 0.23–0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, diarrhea, and treatment-related deaths between two groups.
Conclusions.
SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for patients of ACRC, but further investigations in different populations would be needed to confirm it.
American Psychological Association (APA)
Ye, Jiaxiang& Chen, Jiawei& Ge, Lianying& Liu, Aiqun& Zhou, Shaozhang. 2014. Effectiveness and Safety of S-1-Based Therapy Compared with 5-Fluorouracil-Based Therapy for Advanced Colorectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035873
Modern Language Association (MLA)
Ye, Jiaxiang…[et al.]. Effectiveness and Safety of S-1-Based Therapy Compared with 5-Fluorouracil-Based Therapy for Advanced Colorectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035873
American Medical Association (AMA)
Ye, Jiaxiang& Chen, Jiawei& Ge, Lianying& Liu, Aiqun& Zhou, Shaozhang. Effectiveness and Safety of S-1-Based Therapy Compared with 5-Fluorouracil-Based Therapy for Advanced Colorectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035873