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Pharmacologic Prophylaxis of Portal Venous System Thrombosis after Splenectomy: A Meta-Analysis
Joint Authors
Fan, Daiming
Bai, Ming
Guo, Xiaozhong
Qi, Xingshun
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Portal venous system thrombosis (PVST) is a life-threatening complication of splenectomy.
A meta-analysis was conducted to explore the role of pharmacologic prophylaxis of PVST after splenectomy.
Overall, 359 papers were initially identified via the PubMed, EMBASE, and Cochrane Library databases.
Eight of them were eligible.
The incidence of PVST after splenectomy was significantly lower in patients who received the preventive measures than in those who did not (odds ratio [OR]: 0.33, 95% confidence interval [CI]: 0.22–0.47, P<0.00001).
Subgroup analyses demonstrated that the significant difference remained in studies including patients with portal hypertension (n=6), but not in those including patients with hematological diseases (n=2); the significant difference remained in studies using any type of prophylactic drugs (anticoagulants [n=6], thrombolytics [n=1], and prostaglandin E1 [n=1]); the significant difference remained in nonrandomized studies (n=5), but not in randomized studies (n=3).
The risk of bleeding was similar between the two groups (OR: 0.65, 95% CI: 0.10–4.04, P=0.64).
In conclusion, pharmacologic prophylaxis might decrease the incidence of PVST after splenectomy in patients with portal hypertension and did not increase the risk of bleeding.
However, the effect of pharmacologic prophylaxis of PVST in patients with hematological diseases remained questioned.
American Psychological Association (APA)
Qi, Xingshun& Bai, Ming& Guo, Xiaozhong& Fan, Daiming. 2014. Pharmacologic Prophylaxis of Portal Venous System Thrombosis after Splenectomy: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035880
Modern Language Association (MLA)
Qi, Xingshun…[et al.]. Pharmacologic Prophylaxis of Portal Venous System Thrombosis after Splenectomy: A Meta-Analysis. Gastroenterology Research and Practice No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035880
American Medical Association (AMA)
Qi, Xingshun& Bai, Ming& Guo, Xiaozhong& Fan, Daiming. Pharmacologic Prophylaxis of Portal Venous System Thrombosis after Splenectomy: A Meta-Analysis. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035880