Flt3Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis
Joint Authors
Mao, Jing-Wei
Huang, Yu-Shuang
Tang, Hai-Ying
Bi, Jian
Liu, Yan-Fei
Wang, Ying-De
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The immunoregulation between dendritic cells (DCs) and regulatory T cells (T-regs) plays an important role in the pathogenesis of ulcerative colitis (UC).
Recent research showed that Fms-like tyrosine kinase 3 (Flt3) and Flt3 ligand (Flt3L) were involved in the process of DCs regulating T-regs.
The DSS-induced colitis model is widely used because of its simplicity and many similarities with human UC.
In this study, we observe the disease activity index (DAI) and histological scoring, detect the amounts of DCs and T-regs and expression of Flt3/Flt3L, and investigate Flt3/Flt3L participating in the process of DCs regulating T-regs in DSS-induced colitis.
Our findings suggest that the reduction of Flt3 and Flt3L expression may possibly induce colonic immunoregulatory imbalance between CD103+MHCII+DCs and CD4+CD25+FoxP3+T-regs in DSS-induced colitis.
Flt3/Flt3L participates in the process of regulating DCS and T-regs in the pathogenesis of UC, at least, in the acute stage of this disease.
American Psychological Association (APA)
Mao, Jing-Wei& Huang, Yu-Shuang& Tang, Hai-Ying& Bi, Jian& Liu, Yan-Fei& Wang, Ying-De. 2014. Flt3Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035889
Modern Language Association (MLA)
Mao, Jing-Wei…[et al.]. Flt3Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis. Gastroenterology Research and Practice No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035889
American Medical Association (AMA)
Mao, Jing-Wei& Huang, Yu-Shuang& Tang, Hai-Ying& Bi, Jian& Liu, Yan-Fei& Wang, Ying-De. Flt3Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035889
