Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models
Joint Authors
Poscente, Michael D.
Wang, Gang
Filip, Dobromir
Ninova, Polya
Muench, Gregory
Yadid-Pecht, Orly
Mintchev, Martin P.
Andrews, Christopher N.
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Transcutaneous intraluminal impedance measurement (TIIM) is a new method to cutaneously measure gastric contractions by assessing the attenuation dynamics of a small oscillating voltage emitted by a battery-powered ingestible capsule retained in the stomach.
In the present study, we investigated whether TIIM can reliably assess gastric motility in acute canine models.
Methods.
Eight mongrel dogs were randomly divided into 2 groups: half received an active TIIM pill and half received an identically sized sham capsule.
After 24-hour fasting and transoral administration of the pill (active or sham), two force transducers (FT) were sutured onto the antral serosa at laparotomy.
After closure, three standard cutaneous electrodes were placed on the abdomen, registering the transluminally emitted voltage.
Thirty-minute baseline recordings were followed by pharmacological induction of gastric contractions using neostigmine IV and another 30-minute recording.
Normalized one-minute baseline and post-neostigmine gastric motility indices (GMIs) were calculated and Pearson correlation coefficients (PCCs) between cutaneous and FT GMIs were obtained.
Statistically significant GMI PCCs were seen in both baseline and post-neostigmine states.
There were no significant GMI PCCs in the sham capsule test.
Further chronic animal studies of this novel long-term gastric motility measurement technique are needed before testing it on humans.
American Psychological Association (APA)
Poscente, Michael D.& Wang, Gang& Filip, Dobromir& Ninova, Polya& Muench, Gregory& Yadid-Pecht, Orly…[et al.]. 2014. Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035896
Modern Language Association (MLA)
Poscente, Michael D.…[et al.]. Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models. Gastroenterology Research and Practice No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035896
American Medical Association (AMA)
Poscente, Michael D.& Wang, Gang& Filip, Dobromir& Ninova, Polya& Muench, Gregory& Yadid-Pecht, Orly…[et al.]. Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035896