Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis
Joint Authors
Li, Qiang
Liu, Ying
Zhang, Hong-Mei
Huang, Yin-Peng
Wang, Tian-Yi
Li, Dong-Sheng
Sun, Hong-Zhi
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Our meta-analysis aggregated existing results from relevant studies to comprehensively investigate the correlations between genetic polymorphisms in dihydropyrimidine dehydrogenase (DPYD) gene and 5-fluorouracil (5-FU) toxicities in patients with colorectal cancer (CRC).
The MEDLINE (1966∼2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980∼2013), CINAHL (1982∼2013), Web of Science (1945∼2013), and the Chinese Biomedical Database (CBM) (1982∼2013) were searched without language restrictions.
Meta-analyses were conducted with the use of STATA software (Version 12.0, Stata Corporation, College Station, TX, USA).
Seven clinical cohort studies with a total of 946 CRC patients met our inclusion criteria, and NOS scores of each of the included studies were ≥5.
Our findings showed that DPYD genetic polymorphisms were significantly correlated with high incidences of 5-FU-related toxicity in CRC patients.
SNP-stratified analysis indicated that there were remarkable connections of IVS14+1G>A, 464T>A, and 2194G>A polymorphisms with the incidence of marrow suppression in CRC patients receiving 5-FU chemotherapy.
Furthermore, we found that IVS14+1G>A, 496A>G, and 2194G>A polymorphisms were correlated with the incidence of gastrointestinal reaction.
Ethnicity-stratified analysis also revealed that DPYD genetic polymorphisms might contribute to the development of marrow suppression and gastrointestinal reaction among Asians, but not among Caucasians.
The present meta-analysis suggests that DPYD genetic polymorphisms may be correlated with the incidence of 5-FU-related toxicity in CRC patients.
American Psychological Association (APA)
Li, Qiang& Liu, Ying& Zhang, Hong-Mei& Huang, Yin-Peng& Wang, Tian-Yi& Li, Dong-Sheng…[et al.]. 2014. Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035902
Modern Language Association (MLA)
Li, Qiang…[et al.]. Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035902
American Medical Association (AMA)
Li, Qiang& Liu, Ying& Zhang, Hong-Mei& Huang, Yin-Peng& Wang, Tian-Yi& Li, Dong-Sheng…[et al.]. Influence of DPYD Genetic Polymorphisms on 5-Fluorouracil Toxicities in Patients with Colorectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035902