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S100A8 and S100A9 Positive Cells in Colorectal Carcinoma: Clinicopathological Analysis
Joint Authors
Başsorgun, Cumhur İbrahim
Erin, Nuray
Özlük, Anıl
Uzun, Özlem Ceren
Elpek, Gulsum Ozlem
Ünal, Betül
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
In colorectal carcinoma, tumoral tissues infiltrate with various immune/inflammatory cells along their invasive margins and the increased S100A8/A9 expression in these immune cells infiltrating the tumor has recently been demonstrated.
We examined S100A8/A9 as a potential therapeutic target in the treatment of colorectal carcinoma.
Materials and Methods.
The current study included a sample of 80 patients diagnosed with CRC (30 cases with distant metastasis, 30 cases with lymph node metastasis, and 20 cases with no metastasis).
Peritumoral and intratumoral S100A8 and S100A9 expressing inflammatory cells were counted in primary tumors and their metastasis and correlated with clinicopathological parameters.
Results.
The peritumoral and intratumoral S100A8/A9 positive cells showed no correlation with age, gender, or depth of tumor invasion.
However higher counts of peritumoral and intratumoral S100A8/A9 positive cells were associated with larger tumor size, higher grade, and the presence of metastasis (P<0.05).
Conclusion.
Our study also found significantly higher number of S100A8/A9 positive cells in the tumor microenvironment among patients with large tumor size, high grade, and metastatic disease.
Moreover, in our study, we observed that the expression in the tumor metastasis appeared similar to that of primary tumor.
American Psychological Association (APA)
Başsorgun, Cumhur İbrahim& Ünal, Betül& Erin, Nuray& Özlük, Anıl& Uzun, Özlem Ceren& Elpek, Gulsum Ozlem. 2014. S100A8 and S100A9 Positive Cells in Colorectal Carcinoma: Clinicopathological Analysis. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035911
Modern Language Association (MLA)
Başsorgun, Cumhur İbrahim…[et al.]. S100A8 and S100A9 Positive Cells in Colorectal Carcinoma: Clinicopathological Analysis. Gastroenterology Research and Practice No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035911
American Medical Association (AMA)
Başsorgun, Cumhur İbrahim& Ünal, Betül& Erin, Nuray& Özlük, Anıl& Uzun, Özlem Ceren& Elpek, Gulsum Ozlem. S100A8 and S100A9 Positive Cells in Colorectal Carcinoma: Clinicopathological Analysis. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035911