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Cervical Dysplasia and High-Risk Human Papillomavirus Infections among HIV-Infected and HIV-Uninfected Adolescent Females in South Africa
Joint Authors
Adler, David H.
Wallace, Melissa
Bennie, Thola
Mrubata, Megan
Abar, Beau
Meiring, Tracy L.
Bekker, Linda-Gail
Williamson, Anna-Lise
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
HIV-infected adolescents may be at higher risk for high-grade cervical lesions than HIV-uninfected adolescents.
The purpose of this study was to compare the prevalence of high-risk HPV (HR-HPV) infections and Pap smear abnormalities between these two groups.
Methods.In this cross-sectional study, we compared the HPV DNA and Pap smear results between 35 HIV-infected and 50 HIV-uninfected adolescents in order to determine the prevalence of HR-HPV genotypes and cervical cytological abnormalities.
Comparisons were made using Pearson χ2 and independent-samples t-tests analyses, and associations between demographic and behavioral characteristics and HPV infections were examined.
Results.
HIV-infected participants were more likely to be infected with any HPV (88.6% versus 48.0%; P<0.001) and with at least one HR-HPV (60.0% versus 24.0%; P=0.001), and to have multiple concurrent HPV infections (68.6% versus 22.0%; P<0.001).
HPV 16 and 18 were relatively underrepresented among HR-HPV infections.
Abnormal Pap test results were more common among HIV-infected participants (28.8% versus 12.0%; P=0.054).
A history of smoking was associated with HR-HPV infection.
Conclusions.
HIV-infected adolescents have an increased risk of infection with HR-HPV and of Pap test abnormalities.
The majority of HR-HPV infections among our participants would not be prevented by the currently available vaccinations against HPV.
American Psychological Association (APA)
Adler, David H.& Wallace, Melissa& Bennie, Thola& Mrubata, Megan& Abar, Beau& Meiring, Tracy L.…[et al.]. 2014. Cervical Dysplasia and High-Risk Human Papillomavirus Infections among HIV-Infected and HIV-Uninfected Adolescent Females in South Africa. Infectious Diseases in Obstetrics and Gynecology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035914
Modern Language Association (MLA)
Adler, David H.…[et al.]. Cervical Dysplasia and High-Risk Human Papillomavirus Infections among HIV-Infected and HIV-Uninfected Adolescent Females in South Africa. Infectious Diseases in Obstetrics and Gynecology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035914
American Medical Association (AMA)
Adler, David H.& Wallace, Melissa& Bennie, Thola& Mrubata, Megan& Abar, Beau& Meiring, Tracy L.…[et al.]. Cervical Dysplasia and High-Risk Human Papillomavirus Infections among HIV-Infected and HIV-Uninfected Adolescent Females in South Africa. Infectious Diseases in Obstetrics and Gynecology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035914