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Boost IORT in Breast Cancer: Body of Evidence
Joint Authors
Reitsamer, Roland
Fussl, Christoph
Ziegler, Ingrid
Zehentmayr, Franz
Deutschmann, Heinz
Kopp, Peter
Fastner, Gerd
Sedlmayer, Felix
Source
International Journal of Breast Cancer
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The term IORT (intraoperative radiotherapy) is currently used for various techniques that show decisive differences in dose delivery.
The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments with single doses around 10 Gy, providing outstandingly low local recurrence rates in any risk constellation also at long term analyses.
Compared to other boost methods, an intraoperative treatment has evident advantages as follows.
Precision.
Direct visualisation of the tumour bed during surgery guarantees an accurate dose delivery.
This fact has additionally gained importance in times of primary reconstruction techniques after lumpectomy to optimise cosmetic outcome.
IORT is performed before breast tissue is mobilised for plastic purposes.
Cosmesis.
As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance.
Patient Comfort.
Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy.
Its combination with a 3-week hypofractionated external beam radiotherapy to the whole breast (WBI) is presently tested in the HIOB trial (hypofractionated WBI preceded by IORT electron boost), a prospective multicenter trial of the International Society of Intraoperative Radiotherapy (ISIORT).
American Psychological Association (APA)
Sedlmayer, Felix& Reitsamer, Roland& Fussl, Christoph& Ziegler, Ingrid& Zehentmayr, Franz& Deutschmann, Heinz…[et al.]. 2014. Boost IORT in Breast Cancer: Body of Evidence. International Journal of Breast Cancer،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036302
Modern Language Association (MLA)
Sedlmayer, Felix…[et al.]. Boost IORT in Breast Cancer: Body of Evidence. International Journal of Breast Cancer No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036302
American Medical Association (AMA)
Sedlmayer, Felix& Reitsamer, Roland& Fussl, Christoph& Ziegler, Ingrid& Zehentmayr, Franz& Deutschmann, Heinz…[et al.]. Boost IORT in Breast Cancer: Body of Evidence. International Journal of Breast Cancer. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036302