![](/images/graphics-bg.png)
Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier
Joint Authors
Dias Murbach, Heitor
Jaques Ogawa, Guilherme
Azevedo Borges, Felipe
Romeiro Miranda, Matheus Carlos
Lopes, Rute
Roberto de Barros, Natan
Guedes Mazalli, Alexandre Vinicius
Gonçalves da Silva, Rosângela
Ferreira Cinman, José Luiz
de Camargo Drago, Bruno
Donizetti Herculano, Rondinelli
Source
International Journal of Biomaterials
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance.
Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice.
The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior.
CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy.
Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian).
The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.
American Psychological Association (APA)
Dias Murbach, Heitor& Jaques Ogawa, Guilherme& Azevedo Borges, Felipe& Romeiro Miranda, Matheus Carlos& Lopes, Rute& Roberto de Barros, Natan…[et al.]. 2014. Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier. International Journal of Biomaterials،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036327
Modern Language Association (MLA)
Dias Murbach, Heitor…[et al.]. Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier. International Journal of Biomaterials No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036327
American Medical Association (AMA)
Dias Murbach, Heitor& Jaques Ogawa, Guilherme& Azevedo Borges, Felipe& Romeiro Miranda, Matheus Carlos& Lopes, Rute& Roberto de Barros, Natan…[et al.]. Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier. International Journal of Biomaterials. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036327