Determination of Oxidative Stress Related Toxicity on Repeated Dermal Exposure of Hydroxyapatite Nanoparticles in Rats
Joint Authors
Mohanan, P. V.
Santhakumar, Syama
Arumugam, Sabareeswaran
Source
International Journal of Biomaterials
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hydroxyapatite nanoparticles (HANPs) have numerous applications, such as substitute for bone grafting, bone fillers, bioceramic coating, and dental fillings.
The toxicity of these nanomaterials is of growing concern despite their significant scientific interest and promising potential in many applications.
In this study, an in-house synthesized, characterized HANP of size <50 nm was investigated for the dermal toxicity.
A paste of HANPs was prepared in water and applied on the dorsal side of the rats for 28 days.
At the end of 28 days, blood was subjected to haematological and biochemical analysis.
Gross necropsy was conducted and major organs were collected for histopathological observations.
Liver from the animals was evaluated for lipid peroxidation, reduced glutathione, and antioxidant enzymes activity.
It was observed that none of the animals showed any abnormality during the experimental period.
Gross examination of carcasses did not reveal any abnormality in the organs examined.
The results also demonstrated that there was no significant fluctuation in the level of antioxidant defense mechanisms, lipid peroxidation, and haematological and biochemical parameters.
There was no histopathological lesion observed in any of the organs.
Hence, it can be concluded that the synthesized HANPs were nontoxic at cellular level, when exposed dermally to rats.
American Psychological Association (APA)
Mohanan, P. V.& Santhakumar, Syama& Arumugam, Sabareeswaran. 2014. Determination of Oxidative Stress Related Toxicity on Repeated Dermal Exposure of Hydroxyapatite Nanoparticles in Rats. International Journal of Biomaterials،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036331
Modern Language Association (MLA)
Mohanan, P. V.…[et al.]. Determination of Oxidative Stress Related Toxicity on Repeated Dermal Exposure of Hydroxyapatite Nanoparticles in Rats. International Journal of Biomaterials No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036331
American Medical Association (AMA)
Mohanan, P. V.& Santhakumar, Syama& Arumugam, Sabareeswaran. Determination of Oxidative Stress Related Toxicity on Repeated Dermal Exposure of Hydroxyapatite Nanoparticles in Rats. International Journal of Biomaterials. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036331