The “CROMa” Project: A Care Pathway for Clinical Management of Patients with Bisphosphonate Exposure
Joint Authors
Capocci, Mauro
Cocco, Fabio
Bignozzi, Isabella
Annibali, Susanna
Ottolenghi, Livia
Umberto, Romeo
Source
International Journal of Dentistry
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To describe 7 years of activity of “CROMa” (Coordination of Research on Osteonecrosis of the Jaws) project of “Sapienza” University of Rome.
Materials and Methods.
A preventive and therapeutic care pathway was created for patients with bisphosphonates (BPs) exposure.
Demographic, social, behavioural, pharmacological, and clinical variables were registered in a dedicated database.
Results.
In the project, 502 patients, 403 females and 99 males, were observed.
Bone pathologies were 79% osteometabolic diseases (OMD) and 21% metastatic cancer (CA).
Females were 90% in OMD group and 41% in CA.
BP administration was 54% oral, 31% IV, and 11% IM; 89% of BPs were amino-BP and 11% non-amino-BP.
Consistently with bone pathology (OMD/CA), alendronate appears to be prevalent for OMD (40% relative), while zoledronate was indicated in 92% of CA patients.
Out of 502 cases collected, 28 BRONJ were detected: 17 of them were related to IV BP treatment.
Preventive oral assessment was required for 50% of CA patients and by 4% of OMD patients.
Conclusions.
The proposed care pathway protocols for BP exposed patients appeared to be useful to meet treatment and preventive needs, in both oncological and osteometabolic diseases patients.
Patients’ and physicians’ prevention awareness can be the starting point of a multilevel prevention system.
American Psychological Association (APA)
Capocci, Mauro& Umberto, Romeo& Cocco, Fabio& Bignozzi, Isabella& Annibali, Susanna& Ottolenghi, Livia. 2014. The “CROMa” Project: A Care Pathway for Clinical Management of Patients with Bisphosphonate Exposure. International Journal of Dentistry،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036383
Modern Language Association (MLA)
Capocci, Mauro…[et al.]. The “CROMa” Project: A Care Pathway for Clinical Management of Patients with Bisphosphonate Exposure. International Journal of Dentistry No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036383
American Medical Association (AMA)
Capocci, Mauro& Umberto, Romeo& Cocco, Fabio& Bignozzi, Isabella& Annibali, Susanna& Ottolenghi, Livia. The “CROMa” Project: A Care Pathway for Clinical Management of Patients with Bisphosphonate Exposure. International Journal of Dentistry. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036383