Ethynilestradiol 20 mcg plus Levonorgestrel 100 mcg: Clinical Pharmacology
Joint Authors
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Estroprogestins (EPs) are combinations of estrogen and progestin with several actions on women’s health.
The different pharmacological composition of EPs is responsible for different clinical effects.
One of the most used low-dose EP associations is ethinylestradiol 20 mcg plus levonorgestrel 100 mcg in monophasic regimen (EE20/LNG100).
This review summarizes clinical pharmacology, cycle control, and effects on lipid and glucose metabolism, coagulation, body weight/body composition, acne, and sexuality of EE20/LNG100.
Overall, EE20/LNG100 combination is safe and well tolerated, and in several studies the incidence of adverse events in the treated group was comparable to that of the placebo group.
Cycle control was effective and body weight/body composition did not vary among treated and untreated groups in most studies.
The EE20/LNG100 combination shows mild or no effect on lipid and glucose metabolism.
Lastly, EE20/LNG100 is associated with a low risk of venous thromboembolism (VTE).
In conclusion, in the process of decision making for the individualization of EPs choice, EE20/LNG100 should be considered for its favorable clinical profile.
American Psychological Association (APA)
Lello, Stefano& Cavani, Andrea. 2014. Ethynilestradiol 20 mcg plus Levonorgestrel 100 mcg: Clinical Pharmacology. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036405
Modern Language Association (MLA)
Lello, Stefano& Cavani, Andrea. Ethynilestradiol 20 mcg plus Levonorgestrel 100 mcg: Clinical Pharmacology. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036405
American Medical Association (AMA)
Lello, Stefano& Cavani, Andrea. Ethynilestradiol 20 mcg plus Levonorgestrel 100 mcg: Clinical Pharmacology. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036405