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Study of Microvessel Density and the Expression of Vascular Endothelial Growth Factors in Adrenal Gland Pheochromocytomas
Joint Authors
Białas, Magdalena
Dyduch, Grzegorz
Dudała, Joanna
Bereza-Buziak, Monika
Budzyński, Andrzej
Okoń, Krzysztof
Hubalewska-Dydejczyk, A.
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Angiogenesis (neoangiogenesis), a process of neovascularization, is an essential step for local tumor growth and distant metastasis formation.
We have analysed angiogenesis status: vascular architecture, microvessel density, and vascular endothelial growth factors expression in 62 adrenal pheochromocytomas: 57 benign and 5 malignant.
Immunohistochemical evaluation revealed that vascular architecture and vessel density are different in the central and subcapsular areas of the tumor.
Furthermore, we have observed a strong correlation between number of macrophages and microvessel density in the central and subcapsular areas of the tumor and between the expression of VEGF-A in tumor cells and microvessel density in central and subcapsular areas of the tumor.
Secondary changes in these tumors influence the results and both vascular architecture and microvessel density are markedly disturbed by hemorrhagic and cystic changes in pheochromocytomas.
These changes are partially caused by laparoscopic operation technique.
However, no differences in vascular parameters were found between pheochromocytomas with benign and malignant clinical behavior.
Our observation showed that analysis of angiogenesis, as a single feature, does not help in differentiating malignant and benign pheochromocytomas and has no independent prognostic significance.
On the other hand, high microvessel density in pheochromocytoma is a promising factor for antiangiogenic therapy in malignant cases.
American Psychological Association (APA)
Białas, Magdalena& Dyduch, Grzegorz& Dudała, Joanna& Bereza-Buziak, Monika& Budzyński, Andrzej& Okoń, Krzysztof…[et al.]. 2014. Study of Microvessel Density and the Expression of Vascular Endothelial Growth Factors in Adrenal Gland Pheochromocytomas. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036408
Modern Language Association (MLA)
Budzyński, Andrzej…[et al.]. Study of Microvessel Density and the Expression of Vascular Endothelial Growth Factors in Adrenal Gland Pheochromocytomas. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036408
American Medical Association (AMA)
Białas, Magdalena& Dyduch, Grzegorz& Dudała, Joanna& Bereza-Buziak, Monika& Budzyński, Andrzej& Okoń, Krzysztof…[et al.]. Study of Microvessel Density and the Expression of Vascular Endothelial Growth Factors in Adrenal Gland Pheochromocytomas. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036408