Association between Lower Normal Free Thyroxine Concentrations and Obesity Phenotype in Healthy Euthyroid Subjects
Joint Authors
Shin, Jeong Ah
Mo, Eun young
Kim, Eun Sook
Moon, Sung Dae
Han, Je Ho
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigated whether thyroid function could identify obesity phenotype in euthyroid subjects.
A cross-sectional analysis was performed among nondiabetic, euthyroid subjects.
We stratified subjects into four groups by BMI and insulin resistance (IR).
Of 6241 subjects, 33.8% were overweight or obese (OW/OB) and 66.2% were normal weight (NW).
Free thyroxine (FT4) levels were negatively associated with body mass index, waist circumference, triglyceride, c-reactive protein, and HOMA-IR and positively with high-density lipoprotein cholesterol in both genders.
In multivariate regression analysis, FT4 level, a continuous measurement, was negatively correlated with HOMA-IR (β=-0.155, P<0.001 in men; β=-0.175, P<0.001 in women).
After adjustment for age, sex, metabolic, and life style factors, subjects in the lowest FT4 quartile had an odds ratio (OR) for IR of 1.99 (95% confidence interval 1.61–2.46), as compared to those in the highest quartile.
The association between low FT4 and IR remained significant in both NW and OW/OB subgroups.
In conclusion, low normal FT4 levels were independently related to IR in NW and OW/OB euthyroid subjects.
Further studies are needed to investigate the mechanisms by which low FT4 levels are linked to high IR in euthyroid ranges.
American Psychological Association (APA)
Shin, Jeong Ah& Mo, Eun young& Kim, Eun Sook& Moon, Sung Dae& Han, Je Ho. 2014. Association between Lower Normal Free Thyroxine Concentrations and Obesity Phenotype in Healthy Euthyroid Subjects. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036410
Modern Language Association (MLA)
Shin, Jeong Ah…[et al.]. Association between Lower Normal Free Thyroxine Concentrations and Obesity Phenotype in Healthy Euthyroid Subjects. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036410
American Medical Association (AMA)
Shin, Jeong Ah& Mo, Eun young& Kim, Eun Sook& Moon, Sung Dae& Han, Je Ho. Association between Lower Normal Free Thyroxine Concentrations and Obesity Phenotype in Healthy Euthyroid Subjects. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036410