The TGHDL-C Ratio Might Be a Surrogate for Insulin Resistance in Chinese Nonobese Women

Abstract EN

Obejective.

To examine the discriminatory power of triglyceride (TG) and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) for insulin resistance (IR) in a normoglycaemic Chinese population.

Methods.

The data were collected from 711 individuals.

The normoglycaemic individuals were eventually included in the study (n = 533, age: 62.8 ± 6.6 years, male: 56.8%), who were with a fasting plasma glucose < 6.1 mmol/L and without a history of diabetes.

IR was defined as the upper quintile (≥1.6) of homeostasis model assessment of IR.

Area under the receiver operating characteristic curve (AROC) was used to examine the discriminatory power.

Results.

The discriminatory power of TG/HDL-C for IR was acceptable in women with a BMI < 24 kg/m2 or waist circumference < 80 cm (AROCs: 0.718 and 0.713, resp.); however, the discriminatory power was not acceptable in the obese women.

TG/HDL-C was not an acceptable marker of IR in men.

The discriminatory power of TG for IR was not acceptable in both men and women.

Conclusions.

The discriminatory power of TG/HDL-C for IR differs by gender and obesity index in the normoglycaemic Chinese population, and TG/HDL-C could discriminate IR in the nonobese and normoglycaemic women.