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Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females
Joint Authors
Merican, Amir Feisal
Rehman, Rehana
Tariq, Saba
Fatima, Syeda Sadia
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The study aimed to investigate the levels of serum leptin in PCOS females and to correlate it with metabolic and hormonal parameters.
Sixty-two PCOS and ninety normal cycling (NC) females with matched age and body mass index (BMI) were recruited for this cross-sectional study.
Serum leptin, FSH, LH, E2, free testosterone, progesterone, thyroid profile, and FBG levels were measured.
The mean leptin levels in PCOS and NC were not significantly different (45.56 ng/mL ± 1.49 vs 41.78 ± 1.31 ng/mL, P>0.05); however, leptin levels showed a strong correlation with BMI in PCOS and NC group (r=0.77, P<0.0001; r=0.82, P<0.0001, resp.).
High E2 levels in NC had a significant correlation with leptin whereas FBG correlated with leptin in PCOS (r=0.51, P=0.005).
TSH had a substantial correlation (r=0.49, P<0.005; r=0.69, P<0.005) in PCOS and NC, respectively.
There was no significant difference found in circulating leptin concentration between PCOS and NC subjects.
Leptin levels in PCOS were related with metabolic impairments manifested by disturbance in FBG levels and impairment of reproductive functions in terms of reduced E2 secretion.
American Psychological Association (APA)
Merican, Amir Feisal& Rehman, Rehana& Tariq, Saba& Fatima, Syeda Sadia. 2014. Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036415
Modern Language Association (MLA)
Merican, Amir Feisal…[et al.]. Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females. International Journal of Endocrinology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1036415
American Medical Association (AMA)
Merican, Amir Feisal& Rehman, Rehana& Tariq, Saba& Fatima, Syeda Sadia. Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036415