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Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats
Joint Authors
Hsu, Chuan-Chih
Chen, Li-Fan
Lin, Mao- Tsun
Tian, Yu-Feng
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We aimed at investigating the effect of honokiol on heatstroke in an experimental rat model.
Sprogue-Dawley rats were divided into 3 groups: normothermic diabetic rats treated with vehicle solution (NTDR+V), heatstroke-diabetic rats treated with vehicle (HSDR+V), and heatstroke rats treated with konokiol (0.5–5 mg/ml/kg) (HSDR+H).
Sixty minutes before the start of heat stress, honokiol or vehicle solution was administered.
(HSDR+H) significantly (a) attenuated hyperthermia, hypotension and hypothalamic ischemia, hypoxia, and neuronal apoptosis; (b) reduced the plasma index of the toxic oxidizing radicals; (c) diminished the indices of hepatic and renal dysfunction; (d) attenuated the plasma systemic inflammatory response molecules; (e) promoted plasma levels of an anti-inflammatory cytokine; (f) reduced the index of infiltration of polymorphonuclear neutrophils in the serum; and (g) promoted the survival time fourfold compared with the (HSDR+V) group.
In conclusion, honokiol protected against the outcome of heatstroke by reducing inflammation and oxidative stress-mediated multiple organ dysfunction in diabetic rats.
American Psychological Association (APA)
Hsu, Chuan-Chih& Chen, Li-Fan& Lin, Mao- Tsun& Tian, Yu-Feng. 2014. Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036416
Modern Language Association (MLA)
Hsu, Chuan-Chih…[et al.]. Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats. International Journal of Endocrinology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036416
American Medical Association (AMA)
Hsu, Chuan-Chih& Chen, Li-Fan& Lin, Mao- Tsun& Tian, Yu-Feng. Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036416