![](/images/graphics-bg.png)
Leptin Effects on the Regenerative Capacity of Human Periodontal Cells
Joint Authors
Jepsen, Søren
Deschner, James
Cirelli, Joni Augusto
Jäger, Andreas
Bourauel, Christoph
Nokhbehsaim, Marjan
Eick, Sigrun
Keser, Sema
Nogueira, Andressa Vilas Boas
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Obesity is increasing throughout the globe and characterized by excess adipose tissue, which represents a complex endocrine organ.
Adipose tissue secrets bioactive molecules called adipokines, which act at endocrine, paracrine, and autocrine levels.
Obesity has recently been shown to be associated with periodontitis, a disease characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium, and also with compromised periodontal healing.
Although the underlying mechanisms for these associations are not clear yet, increased levels of proinflammatory adipokines, such as leptin, as found in obese individuals, might be a critical pathomechanistic link.
The objective of this study was to examine the impact of leptin on the regenerative capacity of human periodontal ligament (PDL) cells and also to study the local leptin production by these cells.
Leptin caused a significant downregulation of growth (TGFβ1, and VEGFA) and transcription (RUNX2) factors as well as matrix molecules (collagen, and periostin) and inhibited SMAD signaling under regenerative conditions.
Moreover, the local expression of leptin and its full-length receptor was significantly downregulated by inflammatory, microbial, and biomechanical signals.
This study demonstrates that the hormone leptin negatively interferes with the regenerative capacity of PDL cells, suggesting leptin as a pathomechanistic link between obesity and compromised periodontal healing.
American Psychological Association (APA)
Nokhbehsaim, Marjan& Keser, Sema& Nogueira, Andressa Vilas Boas& Jäger, Andreas& Jepsen, Søren& Cirelli, Joni Augusto…[et al.]. 2014. Leptin Effects on the Regenerative Capacity of Human Periodontal Cells. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036425
Modern Language Association (MLA)
Nokhbehsaim, Marjan…[et al.]. Leptin Effects on the Regenerative Capacity of Human Periodontal Cells. International Journal of Endocrinology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1036425
American Medical Association (AMA)
Nokhbehsaim, Marjan& Keser, Sema& Nogueira, Andressa Vilas Boas& Jäger, Andreas& Jepsen, Søren& Cirelli, Joni Augusto…[et al.]. Leptin Effects on the Regenerative Capacity of Human Periodontal Cells. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036425