Rare Mutations of Peroxisome Proliferator-Activated Receptor Gamma: Frequencies and Relationship with Insulin Resistance and Diabetes Risk in the Mixed Ancestry Population from South Africa
Joint Authors
Vergotine, Z.
Erasmus, R. T.
Yako, Y. Y.
Matsha, T. E.
Kengne, Andre Pascal
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Genetic variants in the nuclear transcription receptor, PPARG, are associated with cardiometabolic traits, but reports remain conflicting.
We determined the frequency and the clinical relevance of PPARG SNPs in an African mixed ancestry population.
Methods.
In a cross-sectional study, 820 participants were genotyped for rs1800571, rs72551362, rs72551363, rs72551364, and rs3856806, using allele-specific TaqMan technology.
The homeostatic model assessment of insulin (HOMA-IR), β-cells function (HOMA-B%), fasting insulin resistance index (FIRI), and the quantitative insulin-sensitivity check index (QUICKI) were calculated.
Results.
No sequence variants were found except for the rs3856806.
The frequency of the PPARG-His447His variant was 23.8% in the overall population group, with no difference by diabetes status ( P = 0.215 ).
The His447His allele T was associated with none of the markers of insulin resistance overall and by diabetes status.
In models adjusted for 2-hour insulin, the T allele was associated with lower prevalent diabetes risk (odds ratio 0.56 (95% CI 0.31–0.95)).
Conclusion.
Our study confirms the almost zero occurrences of known rare PPARG SNPs and has shown for the first time in an African population that one of the common SNPs, His447His, may be protective against type 2 diabetes.
American Psychological Association (APA)
Vergotine, Z.& Kengne, Andre Pascal& Erasmus, R. T.& Yako, Y. Y.& Matsha, T. E.. 2014. Rare Mutations of Peroxisome Proliferator-Activated Receptor Gamma: Frequencies and Relationship with Insulin Resistance and Diabetes Risk in the Mixed Ancestry Population from South Africa. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036428
Modern Language Association (MLA)
Vergotine, Z.…[et al.]. Rare Mutations of Peroxisome Proliferator-Activated Receptor Gamma: Frequencies and Relationship with Insulin Resistance and Diabetes Risk in the Mixed Ancestry Population from South Africa. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036428
American Medical Association (AMA)
Vergotine, Z.& Kengne, Andre Pascal& Erasmus, R. T.& Yako, Y. Y.& Matsha, T. E.. Rare Mutations of Peroxisome Proliferator-Activated Receptor Gamma: Frequencies and Relationship with Insulin Resistance and Diabetes Risk in the Mixed Ancestry Population from South Africa. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036428