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Cannabinoid Receptor 1 Gene Polymorphisms and Nonalcoholic Fatty Liver Disease in Women with Polycystic Ovary Syndrome and in Healthy Controls
Joint Authors
Kuliczkowska Plaksej, Justyna
Laczmanski, Lukasz
Milewicz, Andrzej
Lenarcik-Kabza, A.
Trzmiel-Bira, Anna
Zaleska-Dorobisz, Urszula
Lwow, Felicja
Hirnle, Lidia
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Context.
Polycystic ovary syndrome (PCOS) is frequently associated with nonalcoholic fatty liver disease (NAFLD).
The endocannabinoid system may play a crucial role in the pathogenesis of NAFLD.
Polymorphism of the cannabinoid receptor 1 gene (CNR1) may be responsible for individual susceptibility to obesity and related conditions.
Objective.
To determine the role of genetic variants of CNR1 in the etiopathology of NAFLD in women with PCOS.
Design and Setting.
Our department (a tertiary referral center) conducted a cross-sectional, case-controlled study.
Subjects.
173 women with PCOS (aged 20–35) and 125 healthy, age- and weight-matched controls were studied.
Methods.
Hepatic steatosis was assessed by ultrasound evaluation.
Single nucleotide polymorphisms of CNR1 (rs806368, rs12720071, rs1049353, rs806381, rs10485170, rs6454674) were genotyped.
Results.
Frequency of the G allele of rs806381 (P<0.025) and the GG genotype of rs10485170 (P<0.03) was significantly higher in women with PCOS and NAFLD than in PCOS women without NAFLD.
Frequency of the TT genotype of rs6454674 was higher in PCOS women with NAFLD (not significantly, P=0.059).
In multivariate stepwise regression, allele G of rs806381 was associated with PCOS + NAFLD phenotype.
Conclusion.
Our preliminary results suggest the potential role of CNR1 polymorphisms in the etiology of NAFLD, especially in PCOS women.
American Psychological Association (APA)
Kuliczkowska Plaksej, Justyna& Laczmanski, Lukasz& Milewicz, Andrzej& Lenarcik-Kabza, A.& Trzmiel-Bira, Anna& Zaleska-Dorobisz, Urszula…[et al.]. 2014. Cannabinoid Receptor 1 Gene Polymorphisms and Nonalcoholic Fatty Liver Disease in Women with Polycystic Ovary Syndrome and in Healthy Controls. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036437
Modern Language Association (MLA)
Kuliczkowska Plaksej, Justyna…[et al.]. Cannabinoid Receptor 1 Gene Polymorphisms and Nonalcoholic Fatty Liver Disease in Women with Polycystic Ovary Syndrome and in Healthy Controls. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036437
American Medical Association (AMA)
Kuliczkowska Plaksej, Justyna& Laczmanski, Lukasz& Milewicz, Andrzej& Lenarcik-Kabza, A.& Trzmiel-Bira, Anna& Zaleska-Dorobisz, Urszula…[et al.]. Cannabinoid Receptor 1 Gene Polymorphisms and Nonalcoholic Fatty Liver Disease in Women with Polycystic Ovary Syndrome and in Healthy Controls. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036437