Effect of GHIGF-1 on Bone Metabolism and Osteoporsosis
Joint Authors
Locatelli, Vittorio
Bianchi, Vittorio E.
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
Background.
Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health throughout life.
GH increases tissue formation by acting directly and indirectly on target cells; IGF-1 is a critical mediator of bone growth.
Clinical studies reporting the use of GH and IGF-1 in osteoporosis and fracture healing are outlined.
Methods.
A Pubmed search revealed 39 clinical studies reporting the effects of GH and IGF-1 administration on bone metabolism in osteopenic and osteoporotic human subjects and on bone healing in operated patients with normal GH secretion.
Eighteen clinical studies considered the effect with GH treatment, fourteen studies reported the clinical effects with IGF-1 administration, and seven related to the GH/IGF-1 effect on bone healing.
Results.
Both GH and IGF-1 administration significantly increased bone resorption and bone formation in the most studies.
GH/IGF-1 administration in patients with hip or tibial fractures resulted in increased bone healing, rapid clinical improvements.
Some conflicting results were evidenced.
Conclusions.
GH and IGF-1 therapy has a significant anabolic effect.
GH administration for the treatment of osteoporosis and bone fractures may greatly improve clinical outcome.
GH interacts with sex steroids in the anabolic process.
GH resistance process is considered.
American Psychological Association (APA)
Locatelli, Vittorio& Bianchi, Vittorio E.. 2014. Effect of GHIGF-1 on Bone Metabolism and Osteoporsosis. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-25.
https://search.emarefa.net/detail/BIM-1036439
Modern Language Association (MLA)
Locatelli, Vittorio& Bianchi, Vittorio E.. Effect of GHIGF-1 on Bone Metabolism and Osteoporsosis. International Journal of Endocrinology No. 2014 (2014), pp.1-25.
https://search.emarefa.net/detail/BIM-1036439
American Medical Association (AMA)
Locatelli, Vittorio& Bianchi, Vittorio E.. Effect of GHIGF-1 on Bone Metabolism and Osteoporsosis. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-25.
https://search.emarefa.net/detail/BIM-1036439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036439