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Age as a Prognostic Factor in Anaplastic Thyroid Cancer
Joint Authors
Zivaljevic, Vladan
Tausanovic, Katarina
Paunovic, Ivan
Diklic, Aleksandar
Zoric, Goran
Sabljak, Vera
Vekic, Berislav
Zivic, Rastko
Marinkovic, Jelena
Sipetic, Sandra
Kalezic, Nevena
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Anaplastic thyroid cancer (ATC) is one of the tumors with the shortest survival in human medicine.
Aim.
The aim was to determine the importance of age in survival of patients with ATC.
Material and Methods.
We analyzed the data on 150 patients diagnosed with ATC in the period from 1995 to 2006.
The Kaplan-Meier method and log-rank test were used to determine overall survival.
Prognostic factors were identified by univariate and multivariate Cox regression analysis.
Results.
The youngest patient was 35 years old and the oldest was 89 years old.
According to univariate regression analysis, age was significantly associated with longer survival in patients with ATC.
In multivariate regression analysis, patients age, presence of longstanding goiter, whether surgical treatment is carried out or not, type of surgery, tumor multicentricity, presence of distant metastases, histologically proven preexistent papillary carcinoma, radioiodine therapy, and postoperative radiotherapy were included.
According to multivariate analysis, besides surgery ( P = 0.000 , OR = 0.43, 95% CI = 0.29–0.63), only patients age ( P = 0.023 , OR = 0.68, 95% CI = 0.49–0.95) was independent prognostic factor of favorable survival in patients with ATC.
Conclusion.
Age is a factor that was independently associated with survival time in ATC.
Anaplastic thyroid cancer has the best prognosis in patients younger than 50 years.
American Psychological Association (APA)
Zivaljevic, Vladan& Tausanovic, Katarina& Paunovic, Ivan& Diklic, Aleksandar& Kalezic, Nevena& Zoric, Goran…[et al.]. 2014. Age as a Prognostic Factor in Anaplastic Thyroid Cancer. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036440
Modern Language Association (MLA)
Zivaljevic, Vladan…[et al.]. Age as a Prognostic Factor in Anaplastic Thyroid Cancer. International Journal of Endocrinology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1036440
American Medical Association (AMA)
Zivaljevic, Vladan& Tausanovic, Katarina& Paunovic, Ivan& Diklic, Aleksandar& Kalezic, Nevena& Zoric, Goran…[et al.]. Age as a Prognostic Factor in Anaplastic Thyroid Cancer. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036440