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Effects of Recombinant Human Thyrotropin Administration on 24-Hour Arterial Pressure in Female Undergoing Evaluation for Differentiated Thyroid Cancer
Joint Authors
Stamatelopoulos, Kimon
Alevizaki, Maria
Manios, Efstathios
Zakopoulos, Nikos
Rentziou, Gianna
Saltiki, Katerina
Koroboki, Eleni
Vemmou, Anastasia
Mantzou, Emily
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Thyroid-stimulating-hormone (TSH) receptors are expressed in endothelial cells.
We investigated whether elevated TSH levels after acute recombinant TSH (rhTSH) administration may result in alterations in blood pressure (BP) in premenopausal women with well-differentiated thyroid carcinoma (DTC).
Designs.
Thirty euthyroid DTC female patients were evaluated by rhTSH stimulation test (mean age 40.4±8.6 years).
A 24 h ambulatory systolic and diastolic blood pressure (SBP, DBP) monitoring (24 hr ABPM) was performed on days 2-3(D2-3).
TSH was measured on day 1(D1), day 3(D3), and day 5(D5).
Central blood pressure was evaluated on D3.
Twenty-three patients were studied 1–4 weeks earlier (basal measurements).
Results.
TSH levels were D1: median 0.2 mU/L, D3: median 115.0 mU/L, and D5: median 14.6 mU/L.
There were no significant associations between TSH on D1 and D3 and any BP measurements.
Median D5 office-SBP and 24 h SBP, DBP, and central SBP were correlated with D5-TSH (P<0.04).
In those where a basal 24 h ABPM had been performed median pulse pressure was higher after rhTSH-test (P=0.02).
Conclusions.
TSH, when acutely elevated, may slightly increase SBP, DBP, and central SBP.
This agrees with previous reports showing positive associations of BP with TSH.
American Psychological Association (APA)
Rentziou, Gianna& Saltiki, Katerina& Manios, Efstathios& Stamatelopoulos, Kimon& Koroboki, Eleni& Vemmou, Anastasia…[et al.]. 2014. Effects of Recombinant Human Thyrotropin Administration on 24-Hour Arterial Pressure in Female Undergoing Evaluation for Differentiated Thyroid Cancer. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036445
Modern Language Association (MLA)
Rentziou, Gianna…[et al.]. Effects of Recombinant Human Thyrotropin Administration on 24-Hour Arterial Pressure in Female Undergoing Evaluation for Differentiated Thyroid Cancer. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036445
American Medical Association (AMA)
Rentziou, Gianna& Saltiki, Katerina& Manios, Efstathios& Stamatelopoulos, Kimon& Koroboki, Eleni& Vemmou, Anastasia…[et al.]. Effects of Recombinant Human Thyrotropin Administration on 24-Hour Arterial Pressure in Female Undergoing Evaluation for Differentiated Thyroid Cancer. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036445