Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid
Joint Authors
Bae, Ja-Seong
Choi, Seung Kyu
Jeon, Sora
Kim, Yourha
Lee, Sohee
Lee, Youn Soo
Jung, Chan Kwon
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Most patients with a preoperative diagnosis of thyroid follicular neoplasm (FN) undergo diagnostic surgery to determine whether the nodule is benign or malignant.
Point mutations at NRAS codon 61 are the most common mutations observed in FN.
However, the clinical significance of NRAS mutation remains unclear.
Methods.
From 2012 to 2013, 123 consecutive patients undergoing thyroidectomy for FN were evaluated prospectively.
Molecular analyses for NRAS codon 61 were performed with pyrosequencing.
Results.
The overall malignancy rate in FN was 48.8% (60/123).
Of 123 FNs, 33 (26.8%) were positive for the NRAS mutation.
The sensitivity, specificity, positive predictive value, and negative predictive value of a NRAS mutation-positive FN specimen to predict malignancy were 37%, 83%, 67%, and 58%, respectively.
Patients with a NRAS-positive FN had a higher malignancy rate in additional thyroid nodules beyond the FN than patients with a NRAS-negative FN.
The overall malignancy rate of patients with a NRAS-positive FN was significantly higher than that of patients with a NRAS-negative FN (79% versus 52%; P = 0.008).
Conclusions.
Determining NRAS mutation status in FN helps to improve the accuracy of thyroid cancer diagnosis and to predict cancer risk in accompanying thyroid nodules.
American Psychological Association (APA)
Bae, Ja-Seong& Choi, Seung Kyu& Jeon, Sora& Kim, Yourha& Lee, Sohee& Lee, Youn Soo…[et al.]. 2014. Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036451
Modern Language Association (MLA)
Bae, Ja-Seong…[et al.]. Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid. International Journal of Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036451
American Medical Association (AMA)
Bae, Ja-Seong& Choi, Seung Kyu& Jeon, Sora& Kim, Yourha& Lee, Sohee& Lee, Youn Soo…[et al.]. Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036451