Mild Adrenal Steroidogenic Defects and ACTH-Dependent Aldosterone Secretion in High Blood Pressure: Preliminary Evidence
Joint Authors
Martin Martins, João
do Vale, Sónia
Martins, Ana Filipa
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Adrenal glands play a major role in the control of blood pressure and mild defects of steroidogenesis and/or inappropriate control of mineralocorticoid production have been reported in high blood pressure (HBP).
Patients and Methods.
We used a specific protocol for the evaluation of 100 consecutive patients with inappropriate or recent onset HBP.
Specific methods were used to confirm HBP and to diagnose secondary forms of HBP.
In addition we tested adrenal steroidogenesis with the common cosyntropin test, modified to include the simultaneous measurement of renin and aldosterone besides 17-hydroxyprogesterone (17OHP) and 11-deoxycortisol (S).
Results.
Secondary forms of HBP were diagnosed in 32 patients, including 14 patients with primary hyperaldosteronism (PA) (14%) and 10 patients with pheochromocytoma (10%).
Mild defects of the 21-hydroxylase (21OHD) and 11-hydroxylase (11OHD) enzymes were common (42%).
ACTH-dependent aldosterone secretion was found in most patients (54%) and characteristically in those with mild defects of adrenal steroidogenesis (>60%), PA (>75%), and otherwise in patients with apparent essential HBP (EHBP) (32%).
Discussion.
Mild defects of adrenal steroidogenesis are common in patients with HBP, occurring in almost half of the patients.
In those patients as well as in patients with apparent EHBP, aldosterone secretion is commonly dependent on ACTH.
American Psychological Association (APA)
Martin Martins, João& do Vale, Sónia& Martins, Ana Filipa. 2014. Mild Adrenal Steroidogenic Defects and ACTH-Dependent Aldosterone Secretion in High Blood Pressure: Preliminary Evidence. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036452
Modern Language Association (MLA)
Martin Martins, João…[et al.]. Mild Adrenal Steroidogenic Defects and ACTH-Dependent Aldosterone Secretion in High Blood Pressure: Preliminary Evidence. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036452
American Medical Association (AMA)
Martin Martins, João& do Vale, Sónia& Martins, Ana Filipa. Mild Adrenal Steroidogenic Defects and ACTH-Dependent Aldosterone Secretion in High Blood Pressure: Preliminary Evidence. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036452